上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (7): 1042-.doi: 10.3969/j.issn.1674-8115.2017.07.029

• 综述 • 上一篇    下一篇

强迫症决策功能的神经机制和评估#br#

周月 1，金海燕 2，孙伯民 3，张陈诚 3，占世坤 3   

  1. 上海交通大学  1. 医学院，2. 医学院附属瑞金医院心理科，3. 医学院附属瑞金医院功能神经外科，上海 200025
  • 出版日期:2017-07-28 发布日期:2017-08-25
  • 通讯作者: 占世坤，电子信箱：shikun_zhan@163.com
  • 作者简介:周月（1995—），女，回族，本科生；电子信箱：15121129060@163.com
  • 基金资助:
    国家自然科学基金（81271518, 81471387）；上海交通大学医学院 - 中国科学院神经科学研究所脑疾病临床研究中心项目

Neural mechanism and evaluation of decision-making function in obsessive-compulsive disorder#br#

ZHOU Yue1, JIN Hai-yan2, SUN Bo-min3, ZHANG Chen-cheng3, ZHAN Shi-kun3   

  1. 1. Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2. Department of Psychology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 3. Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2017-07-28 Published:2017-08-25
  • Supported by:
    National Natural Science Foundation of China, 81271518, 81471387; Project from Shanghai Jiao Tong University School of Medicine - Institute of Neuroscience Research Center for Brian Disorder

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摘要： 强迫症是一种复杂的慢性致残性神经精神障碍，从神经生物学基础而言，其与大脑的一些重要脑区如眶额皮质、前扣带皮层 有关。同时，神经影像学研究也表明与决策功能相关的脑区有眶额皮质、背外侧前额叶等。由此可见，强迫症与决策功能有一定的神 经生物学相关性。决策功能受损是强迫症的典型临床表现，而且强迫症的发病与异常决策功能也有相关性。通常决策可分为风险模糊 下决策和风险明确下决策，常用的评估前者的任务主要是爱荷华博弈任务，评估后者的有色子任务等。该文对强迫症中决策功能的神 经机制和评估进行综述。

关键词: 强迫症, 决策功能, 眶额皮质, 爱荷华博弈任务, 色子任务

Abstract:

Obsessive-compulsive disorder (OCD) is a chronic, disabling, mental disorder, which has been linked to significant abnormalities in certain brain areas, including the orbital frontal cortex and the anterior cingulate cortex. Neuroimaging studies have also shown that brain areas related to the decision-making function include the orbital frontal cortex and the dorsal prefrontal lobes. Furthermore, the association between OCD and decisionmaking function has been consistently demonstrated from a neurobiological perspective. Clinically, impaired decision-making ability is commonly observed in OCD patients, and there is a correlation between OCD and abnormal decision function. Decision-making tasks are typically divided into two types, decision-making under risk and decision-making under ambiguity, with the former commonly evaluated using the Iowa Gambling Task (IGT) and the latter using the Game of Dice Task (GDT). In this article the neural mechanism and evaluation methods of decision making in OCD were reviewed.

Key words: obsessive-compulsive disorder, decision making, orbitofrontal cortex, Iowa Gambling Task, Game of Dice Task