上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (7): 1046-.doi: 10.3969/j.issn.1674-8115.2017.07.030

• 综述 • 上一篇    

外泌体及其在肿瘤诊疗中的作用

郑田玉 1，杜君 2，陈宁 2，倪培华 2，薛惠平 1   

  1. 薛惠平，电子信箱：xue_huiping@126.com
  • 出版日期:2017-07-28 发布日期:2017-08-25
  • 作者简介:郑田玉（1994—），女，硕士生；电子信箱：1185693949@qq.com
  • 基金资助:
    上海市自然科学基金面上项目（14ZR1425100）

Roles of exosomes in tumor diagnosis and treatment#br#

ZHENG Tian-yu1, DU Jun2, CHEN Ning2, NI Pei-hua2, XUE Hui-ping1   

  1. 1. Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2.Department of Medical Laboratory, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2017-07-28 Published:2017-08-25
  • Supported by:
    Shanghai Natural Science Foundation, 14ZR1425100

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摘要：  外泌体是多种活细胞分泌的有被小泡，包含有蛋白质、脂质、核酸及多种其他生物大分子。外泌体在很多病理生理过程中发 挥重要作用，如免疫中抗原呈递、组织损伤修复、肿瘤的生长与迁移等。肿瘤来源或肿瘤相关的外泌体在调控肿瘤发生和发展的过程 中扮演重要角色，对肿瘤外泌体的分析和检测可以辅助肿瘤的早期诊断为患者提供新的治疗方法。该文从外泌体的起源、组成及其在 肿瘤发生、发展、迁移、诊断治疗等方面进行综述，为肿瘤治疗提供新的思路。

关键词: &ensp, 外泌体, 微小 RNA, 迁移, 肿瘤标志物, 耐药, 肿瘤治疗

Abstract:

 Exosomes are nanosized membrane microvesicles secreted by various living cells. They contain proteins, lipids, RNA, and a variety of other biological macromolecules. Exosomes play an important role in many pathological and physiological processes, such as antigen presentation in the immune system, repair of damaged tissues, and growth and migration of tumors. Tumor-derived or tumor-associated exosomes play a vital role in regulating the occurrence and development of tumors. The analysis and detection of exosomes in tumors is helpful for the early diagnosis of tumors and provide new treatment methods. This article reviews exosomes’ origin, composition, and functions in the development, migration, diagnosis, and treatment of tumors and provides new ideas for the treatment of tumors.

Key words: exosome, miRNA, migration, tumor markers, drug resistance, oncotherapy