上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (10): 1434-.doi: 10.3969/j.issn.1674-8115.2017.10.025

• 论著（公共卫生） • 上一篇    下一篇

脂联素及其受体在前列腺癌中的作用和研究进展

付什，周娟，王忠   

  1. 上海交通大学 医学院附属第九人民医院泌尿外科，上海 200011
  • 出版日期:2017-10-28 发布日期:2017-11-01
  • 作者简介:付什（1990—），男，硕士生；电子信箱：fu.shi@outlook.com
  • 基金资助:
     国家自然科学基金（81172450）

Research progresses on the role of adiponectin and its receptors in prostate cancer#br#

FU Shi, ZHOU Juan, WANG Zhong   

  1. Department of Urology and Andrology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Online:2017-10-28 Published:2017-11-01
  • Supported by:
     National Natural Science Foundation of China, 81172450

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摘要： 前列腺癌是一种激素相关的恶性肿瘤，其与肥胖在流行病学及分子机制方面的关系密切。脂联素是脂肪细胞合成分泌的一种 脂肪细胞因子，以内分泌的形式作用于全身各个器官，有抗炎、胰岛素增敏、抗增殖和促进凋亡等作用。肥胖可造成脂联素水平的降 低，而脂联素作用的下降与多种肿瘤的发生有密切联系。研究发现前腺癌患者血清脂联素水平下降，前列腺癌组织中脂联素受体下 调，提示脂联素及其受体的功能缺陷可能与前列腺癌的发生、发展有关。该文主要对脂联素和脂联素受体的功能、信号通路及其在前 列腺癌诊断、治疗和预后中的作用进行综述。

关键词: 前列腺癌, 脂联素, 肥胖, 脂联素受体, 脂联素缺陷

Abstract:

Prostate cancer is a hormone-associated malignancy and is closely related to obesity in terms of epidemiology and molecular mechanisms. Adiponectin, an adipocytokine produced by adipokine and secreted by adipocyte, exhibits anti-inflammatory, insulin-sensitizing, anti-proliferation, and proapoptosis actions on various organs in an endocrine form. Obesity leads to a decrease in adiponectin level, which is closely associated with the occurrence of many tumors. Studies have showed that prostate cancer patients had lower serum adiponectin levels and decreased expression of adiponectin receptors in tumor tissues, which suggest that functional defects of adiponectin and its receptors may be relevant to the occurrence and development of prostate cancer. This paper reviews adiponectin and its receptors’ functions, signaling pathways, and roles in diagnosis, treatment, and prognosis of prostate cancer.

Key words: prostate cancer, adiponectin, obesity, adiponectin receptors, adiponectin deficiency