上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (12): 1581-.doi: 10.3969/j.issn.1674-8115.2017.12.001

• 论著（基础研究） • 上一篇    下一篇

神经肽 Y 基因多态性和精神分裂症的关联研究

赵静 1，吕钦谕 1，陆颖 1，胡国芹 1，鲍晨曦 1，朱明环 1，贾思 1，程小燕 1，耿瑞杰 1，姜雅琴 2，禹顺英 1#，#br# 易正辉 1#   

  1. 1. 上海交通大学 医学院附属精神卫生中心，上海 200030；2. 上海市虹口区精神卫生中心，上海 200083
  • 出版日期:2017-12-28 发布日期:2018-01-10
  • 通讯作者: 易正辉，电子信箱：yizhenghui1971@163.com；禹顺英，电子信箱：yushuny@yahoo.com
  • 作者简介:赵 静（1978—），女，主治医生，硕士；电子信箱：maggy-1978@163.com
  • 基金资助:
     “精准医学研究”国家重点专项（2016YFC0906402）；国家重点研发计划（2016YFC1305904）；国家自然科学基金面上项目（81171272, 81671326）；
    上海市科学技术委员会 2017 年度“创新行动计划”医学引导科技支撑项目（17411970000）；上海交通大学文理交叉认知专项基金项目（16JXRZ06）

Relationship between neuropeptide Y gene polymorphism and schizophrenia

ZHAO Jing1, Lü Qin-yu1, LU Ying1, HU Guo-qin1, BAO Chen-xi1, ZHU Ming-huan1, JIA Si1, CHENG Xiao-yan1, GENG Rui-jie1, JIANG Ya-qin2, YU Shun-ying1#, YI Zheng-hui1#     

  1. 1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Shanghai Hongkou District Mental Health Center,
    Shanghai 200083, China
  • Online:2017-12-28 Published:2018-01-10
  • Supported by:
    National Basic Research Program of China “Precision Psychiatry Program”, 2016YFC0906402; National Key R & D Program of China, 2016YFC1305904; National Natural Science Foundation of China, 81171272, 81671326; Shanghai Science and Technology Commission Foundation, 17411970000; The Fundamental Research Funds for the Central Universities of Shanghai Jiao Tong University, 16JXRZ06

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摘要： [ 摘要 ] 目的 · 探讨中国汉族人群神经肽 Y(NPY) 基因多态性与精神分裂症的相关性。方法 · 采用 TaqMan 探针基因分型技术对 678 例精神分裂症患者 ( 病例组 ) 及 685 例正常对照者 ( 对照组 ) 的 NPY 基因多态性（rs16148、rs1859290、rs16147、rs16478）进行分型。应用 SHEsis 在线软件比较各组间的等位基因频率、基因型频率、单倍型频率分布有无差异。结果 · rs16478 位点基因型频率分布在成年起病精神分裂症（AOS）组和对照组间存在边缘统计学差异（χ2=6.66，P=0.036，P 校正 =0.144）。在隐性模式下，rs1859290 位点 CC基因型的频率分布在男性病例组和对照组间差异有统计学意义（P=0.012，OR=0.97，95%CI 为 0.94 ～ 0.99，P 校正 =0.048）。单倍型CCTA（由 rs16148、rs1859290、rs16147、rs16478 构成）的频率分布在男性 AOS 组和对照组间的差异有统计学意义（8.1% vs 13.2%，OR=0.57，P=0.010，P 校正 =0.040）。结论 · 在中国汉族人群中，NPY 基因可能是精神分裂症的易感基因。

关键词: 神经肽 Y, 精神分裂症, 关联分析, 单核苷酸多态性

Abstract:

[Abstract] Objective · To explore the association between neuropeptide Y (NPY) gene polymorphism and schizophrenia in Chinese Han population.
Methods · Four single nucleotide polymorphism (SNP) loci (rs16148, rs1859290, rs16147, and rs16478 in NPY gene) were selected and genotyped
by TaqMan genotyping assay in a case-control study with 678 schizophrenia cases (case group) and 685 healthy controls (control group). The allele,
genotype and haplotype frequencies distribution of the SNPs between the groups were compared with SHEsis online software. Results · The distribution
of genotype frequency of locus rs16478 showed a nominal statistically difference between the adult-onset schizophrenia (AOS group) and control
group (χ2=6.66, P=0.036, P correction=0.144). Under recessive inherited model, the distribution of CC genotype frequency of locus rs1859290 showed
statistically difference between the male schizophrenia cases and control group (P=0.012, OR=0.97, 95%CI 0.94-0.99, P correction=0.048). The
distribution of haplotype CCTA (consisted of rs16148, rs1859290, rs16147, and rs16478) frequency showed statistically difference between the male AOS
group and control group (8.1% vs 13.2%, OR=0.57, P=0.010, P correction=0.040). Conclusion · The polymorphisms in NPY gene may be associated with
schizophrenia in Chinese Han population.

Key words: neuropeptide Y, schizophrenia, association study, single nucleotide polymorphism