上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (4): 463-.doi: 10.3969/j.issn.1674-8115.2018.04.021

• 综述 • 上一篇    下一篇

磷酸甘油酸变位酶1在肿瘤发生及发展中的作用

梁倩 1, 2，沈瑛 1, 2   

  1. 上海交通大学医学院1.药理学与化学生物学系，2. 转化医学协同创新中心，上海 200025
  • 出版日期:2018-04-28 发布日期:2018-05-03
  • 通讯作者: 沈瑛，电子信箱：yshen0510@sjtu.edu.cn。
  • 作者简介:梁倩（1992—），女，硕士生；电子信箱：LQ-sjtu@sjtu.edu.cn。
  • 基金资助:
    国家自然科学基金（81473232，81773748）；上海市卫生和计划生育委员会科研课题（201440576）；上海交通大学医学院科研基金项目（14XJ10002）

Role of phosphoglycerate mutase 1 in the occurence and development of tumor

LIANG Qian1, 2, SHEN Ying1, 2   

  1. 1. Department of Pharmacology and Chemical Biology, 2. Shanghai Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School ofMedicine, Shanghai 200025, China
  • Online:2018-04-28 Published:2018-05-03
  • Supported by:
    National Natural Science Foundation of China, 81473232, 81773748; Project of Shanghai Municipal Commission of Health and Family Planning, 201440576; Foundation ofShanghai Jiao Tong University School of Medicine, 14XJ10002

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摘要： 磷酸甘油酸变位酶1（phosphoglycerate mutase 1，PGAM1）作为糖酵解通路的重要酶之一，在多种肿瘤组织中高表达，并且与肿瘤患者预后呈负相关。PGAM1催化糖酵解通路中3-磷酸甘油酸（3-phosphoglycerate，3-PG）转化生成2-磷酸甘油酸（2-phosphoglycerate，2-PG），促进葡萄糖代谢和能量生成。PGAM1通过调节3-PG与2-PG的转化平衡来影响其他代谢通路，参与细胞内生物大分子合成和维持氧化还原稳态，促进肿瘤细胞增殖及转移。PGAM1作为潜在的抗肿瘤靶标，其抑制剂的研发也成为抗肿瘤药物研究热点之一。该文对PGAM1结构、调控、在肿瘤发生及发展中的作用以及PGAM1抑制剂的最新研究进展作一综述。

关键词: 有氧糖酵解, 磷酸甘油酸变位酶1, 3-磷酸甘油酸, 2-磷酸甘油酸

Abstract:

Phosphoglycerate mutase 1 (PGAM1) as one of the most important enzymes for glycolysis pathway, is highly expressed in multipletumor tissues and negatively correlated with the prognosis of cancer patients. PGAM1 catalyzes the conversion of 3-phosphoglycerate (3-PG) to2-phosphoglycerate (2-PG) in glycolysis pathway, then promoting anabolic pathways, energy generation, and maintaining redox balance during cancercell proliferation and metastasis. The small molecule PGAM1 inhibitors have emerged as a promising strategy for anti-tumor therapy. In this review, the significance of PGAM1 in tumor was reviewed and the research progress of PGAM1 inhibitors was also introduced.

Key words: aerobic glycolysis, phosphoglycerate mutase 1, 3-phosphoglycerate, 2-phosphoglycerate

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