上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (7): 815-.doi: 10.3969/j.issn.1674-8115.2018.07.019

• 综述 • 上一篇    下一篇

miR-195参与精神分裂症发病机制的研究进展

鲍晨曦，吕钦谕，易正辉   

  1. 上海交通大学医学院附属精神卫生中心，上海200030
  • 出版日期:2018-07-28 发布日期:2018-07-30
  • 通讯作者: 易正辉，电子信箱：yizhenghui1971@163.com。
  • 作者简介:鲍晨曦（1992—），女，硕士生；电子信箱：Arysa_bao@163.com。
  • 基金资助:
    国家自然科学基金（81171272，81671326）

Research progress on role of miR-195 in schizophrenia

BAO Chen-xi, Lü Qin-yu, YI Zheng-hui   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2018-07-28 Published:2018-07-30
  • Supported by:
    National Natural Science Foundation of China, 81171272, 81671326

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摘要： 精神分裂症是一组病因未明的重性精神疾病，具有患病率较高、致残率较高和社会负担沉重等特点。研究表明，一些具有调节功能的RNA可能参与了包括精神分裂症在内的多种复杂疾病的发病机制，miRNA就是这样一类可抑制基因表达的非编码RNA。研究发现miRNA在精神分裂症患者大脑组织及外周血中均有显著差异表达。miR-195是miR-15/16/195/497家族的重要成员之一，也是在精神分裂症患者中差异表达的miRNA之一，提示了miR-195可能与精神分裂症的发病机制有关。该文就miR-195功能及其在精神分裂症中作用的研究进展进行综述。

关键词: 精神分裂症, miRNA, miR-195

Abstract:

Schizophrenia is a serious mental health illness with unknown etiology, high prevalence, high morbidity and heavy social burden. Some RNAs with regulatory functions may be involved in pathogenesis of many complex diseases, including schizophrenia. miRNAs are non-coding RNAs that negatively regulate gene . Differential miRNA has been found in the brain and peripheral blood of patients with schizophrenia. miR-195 is an important member of the miR-15/16/195/497 family. Previous studies have implicated that miR-195 may be involved in the pathogenesis of schizophrenia due to its differential . This review aimed to clarify the function of miR-195 and summarized the recent researches of miR-195 in schizophrenia.

Key words: schizophrenia, miRNA, miR-195

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