上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (10): 1167-.doi: 10.3969/j.issn.1674-8115.2019.10.011

• 论著·临床研究 • 上一篇    下一篇

奥氮平血药浓度与细胞色素P450 1A2基因多态性关系的meta分析

汪也微，陈 艳，方新宇，张 毅，蔡 军，宋立升，张 晨   

  1. 上海交通大学医学院附属精神卫生中心生化研究室，上海 200300
  • 出版日期:2019-10-28 发布日期:2019-11-22
  • 通讯作者: 张 晨，电子信箱：zhangchen645@gmail.com。
  • 作者简介:汪也微（1993—），女，硕士生；电子信箱：yuhanwang801@163.com。
  • 基金资助:
    国家自然科学基金（81000581，81471358，81771450）；国家重点研发计划（2018YFC1314302）；国家临床重点专科－上海市精神卫生中心（卫计委医政司2011-873）；上海市科学技术发展基金（12140904200）；上海市教育委员会高峰高原学科建设计划（20152530）

Association of serum olanzapine concentration and cytochrome P450 1A2 gene polymorphisms: a meta-analysis

WANG Ye-wei, CHEN Yan, FANG Xin-yu, ZHANG Yi, CAI Jun, SONG Li-sheng, ZHANG Chen   

  1. Biochemical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200300, China
  • Online:2019-10-28 Published:2019-11-22
  • Supported by:
    National Nature Science Foundation of China, 81000581, 81471358, 81771450; National Key Research and Development Program of China, 2018YFC1314302; National Key Clinical Discipline at Shanghai Mental Health Center, OMA-MH 2011-873; Shanghai Science and Technology Development Funds, 12140904200; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20152530

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摘要： 目的·研究细胞色素P450 1A2（CYP1A2）基因多态性与奥氮平血药浓度变化之间的关系。方法·以关键词“CYP1A2”“基因多态性”“精神分裂症”“奥氮平”“血药浓度”检索 SinoMed、万方、维普、中国知网、PubMed、Embase、Cochrane Library数据库，检索时间段限定为建库至2018年2月27日，并利用STATA/SE 12.0软件进行统计分析。结果·最终纳入4项病例对照研究，包括330例精神分裂症患者。在CYP1A2基因的-163C>A位点隐性模型（A/A vs C/A+C/C）中，携带纯合突变基因型A/A的患者与携带C/A或C/C基因型的患者相比，其奥氮平血药浓度/剂量比（concentration/dosage ratio，C/D）显著降低。结论·CYP1A2基因-163C>A位点的A/A纯合基因型与奥氮平C/D比值降低具有显著相关性。

关键词: 细胞色素P450 1A2, 奥氮平, 血药浓度, 多态性, meta分析

Abstract:

Objective · To investigate association of cytochrome P450 1A2 (CYP1A2) gene polymorphisms and serum olanzapine concentration. Methods · Key words including “cytochrome P450 CYP1A2”, “genetic polymorphism”, “antipsychotic”, “olanzapine”, “schizophrenia”, and “serum concentration” were used to search in databases, including SinoMed, Wanfang, Weipu, CNKI, PubMed, Embase and Cochrane Library. The search period was limited the establishment of the database to February 27th, 2018. STATA/SE 12.0 package was applied to conduct statistical analyses. Results · Four studies with a total of 330 schizophrenic patients were included. In the recessive model of CYP1A2 gene -163C>A SNP, patients with A/A genotype had significantly lower olanzapine concentration/dosage ratio (C/D) than patients with C/C or C/A genotype. Conclusion · A/A homozygote of CYP1A2 gene -163C>A SNP is significantly associated with the decreased olanzapine serum concentration.

Key words: cytochrome P450 1A2, olanzapine, serum drug concentrations, polymorphisms, meta-analysis

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