上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (05): 679-682.doi: 10.3969/j.issn.1674-8115.2020.05.020

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抑郁症语义加工异常脑机制研究进展

叶惠玲，吕 娜，范 青   

  1. 上海交通大学医学院附属精神卫生中心，上海200030
  • 出版日期:2020-05-28 发布日期:2020-05-28
  • 通讯作者: 范 青，电子信箱：fanqing@smhc.org.con。
  • 作者简介:叶惠玲（1996—），女，硕士生；电子信箱：yehuiling0815@163.com。
  • 基金资助:
    国家自然科学基金（81771460）；上海市科学技术委员会“科技创新行动计划”临床医学领域项目（18411952000）；上海市卫生和计划生育委员会面上项目（201740086）。

Review of brain mechanism of abnormal semantic processing in major depression disorder

YE Hui-ling, LÜ Na, FAN Qing   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2020-05-28 Published:2020-05-28
  • Supported by:
    National Natural Science Foundation of China (81771460); Clinical Medicine Project of Shanghai Science and Technology Committee (18411952000)；Shanghai Health and Family Planning Commission Research Project (201740086).

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摘要： 抑郁症是一种致残率高且复发率高的心理疾病，同时伴有语言加工等方面的认知损害。该文回顾了近些年抑郁症患者语义加工异常的神经生理学证据。电生理研究数据表明抑郁症患者语义加工异常起始于感知加工的早期阶段，并在随后的各个加工阶段持续存在，且有大脑半球偏侧化现象。脑影像研究发现抑郁症患者在内侧前额叶皮质和额下回激活水平异常。目前的研究范式还不足以将语义加工与其他认知过程相分离，因此需要更多的研究对其进行探究。

关键词: 抑郁症, 语义加工, 脑机制

Abstract:

Major depression disorder (MDD) is a serious mental illness with high disability rate and high recurrence rate, accompanied by cognitive impairment including language processing. This article reviews neurophysiological evidences of abnormal semantic processing in MDD patients in recent years. Electrophysiological data indicates that abnormal semantic processing in the patients begins in the early stages of perceptual processing and persists in subsequent cognitive processing stages with hemispheric lateralization. Brain imaging studies show that the patients have abnormal activation levels in the medial prefrontal cortex and inferior frontal gyrus. The current research paradigms cannot separate semantic processing from other cognitive processes, and more research is needed.

Key words: major depression disorder (MDD), semantic processing, brain mechanism

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