上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (05): 674-678.doi: 10.3969/j.issn.1674-8115.2020.05.019

• 综述 • 上一篇    下一篇

半乳糖凝集素 -3与心房颤动相关性的研究进展

杨欣颖1，高 谊2，缪从良3，丁晓颖4，洪 江1, 3   

  1. 1. 南京医科大学附属上海一院临床医学院，上海 200080；2. 上海交通大学附属第一人民医院心血管内科，上海 200080；3. 上海交通大学附属第一人民医院急诊危重病科，上海 200080；4. 上海交通大学附属第一人民医院内分泌科，上海200080
  • 出版日期:2020-05-28 发布日期:2020-05-28
  • 通讯作者: 洪 江，电子信箱：jhong.pku@163.com。
  • 作者简介:杨欣颖（1994—），女，硕士生；电子信箱：YangXinying126@126.com。
  • 基金资助:
    国家自然科学基金（81570293，81870594）。

Recent advance in association of galectin-3 with atrial fibrillation

YANG Xin-ying1, GAO Yi2, MIAO Cong-liang3, DING Xiao-ying4, HONG Jiang1, 3   

  1. 1. Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China; 2. Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China; 3. Department of Emergency, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China; 4. Department of Endocrinology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
  • Online:2020-05-28 Published:2020-05-28
  • Supported by:
    National Natural Science Foundation of China (81570293, 81870594).

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摘要： 心房颤动是临床常见的心律失常，病理机制复杂，与心房纤维化等结构重塑密切相关。半乳糖凝集素-3（galectin-3，Gal-3）是半乳糖凝集素家族的唯一嵌合体成员，是纤维化的生物标志物，因此可能参与心房颤动患者的心房重塑。该文就Gal-3与心房颤动的相关性作一简要综述。

关键词: 半乳糖凝集素 -3, 心房颤动, 心房纤维化

Abstract:

Atrial fibrillation is a common cardiac arrhythmia encountered in the clinical practice with a complex pathological mechanism, which is closely related to structural remodeling such as atrial fibrosis. Galectin-3 (Gal-3) is the only chimeric member of the galectin family and is considered as a biomarker of fibrosis; therefore, it may be involved in atrial remodeling in the patients with atrial fibrillation. This article reviews literatures on the association of Gal-3 with atrial fibrillation.

Key words: galectin-3 (Gal-3), atrial fibrillation, atrial fibrosis

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