上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (09): 1256-1262.doi: 10.3969/j.issn.1674-8115.2020.09.015

• 论著·临床研究 • 上一篇    下一篇

酒精所致精神病性障碍男性患者临床特征及危险因素

马银珠*，陆光华*，钟 娜，王海红，和 申，赵 雪，江海峰，王 振   

  1. 上海交通大学医学院附属精神卫生中心成瘾科，上海201100
  • 出版日期:2020-09-28 发布日期:2020-11-04
  • 通讯作者: 王 振，电子信箱：wangzhen@smhc.org.cn。
  • 作者简介:马银珠（1992—），女，满族，硕士生；电子信箱：18642005207@163.com。陆光华（1966—），男，主任医师，学士；电子信箱：lghzyy@126.com。*为共同第一作者。
  • 基金资助:
    上海市教育委员会高峰高原学科建设计划（20161321）；上海市精神卫生中心院级课题（2019-YJ11, 2020-YJ14）；上海市卫生健康委员会科研课题（20204Y0364）。

Clinical characteristics and risk factors of male patients with alcohol-induced psychotic disorders

MA Yin-zhu*, LU Guang-hua*, ZHONG Na, WANG Hai-hong, HE Shen, ZHAO Xue, JIANG Hai-feng , WANG Zhen   

  1. Addiction Department, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 201100, China
  • Online:2020-09-28 Published:2020-11-04
  • Supported by:
    Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (20161321); Hospital-level Project of Shanghai Mental Health Center (2019-YJ11, 2020-YJ14); Scientific Research Project of Shanghai Municipal Health Commission (20204Y0364).

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摘要： 目的·研究酒精（乙醇）所致精神病性障碍男性患者临床特征及危险因素。方法·收集2018年5月—2019年12月上海交通大学医学院附属精神卫生中心成瘾科收治的52例因酒精使用及相关障碍住院男性患者的临床信息，酒精所致精神病性障碍（alcohol-induced psychosis disorder，AIPD）组19例，非AIPD组33例，采用回归分析得到AIPD的危险因素。结果·AIPD患者发生幻视（47.4%）、被害妄想（47.4%）的比例较高；与非AIPD组相比，AIPD组的Logistic回归分析显示血清维生素B12（VB12）水平（P=0.011，OR=0.995）和血清总胆固醇水平（P=0.039，OR=1.874）与AIPD的发生相关。结论·AIPD患者精神症状主要以幻视和被害妄想为主，当血清VB12和血清总胆固醇水平异常时应关注AIPD的发生。

关键词: 酒精, 精神障碍, 维生素B12, 临床特征, 危险因素

Abstract:

Objective · To explore the clinical characteristics and risk factors of male patients with psychotic disorders caused by alcohol. Methods · The clinical data of 52 male inpatients with alcohol use and related disorders treated in the Department of Addiction of Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine from May 2018 to December 2019 were collected. There were 19 cases of alcohol-induced psychotic disorder (alcohol-induced psychosis disorder, AIPD) group and 33 cases of non-AIPD group. The risk factors of AIPD were obtained by regression analysis. Results · AIPD patients had a higher incidence of hallucinations (47.4%) and delusions of murder (47.4%). Compared with non-AIPD groups, Logistic regression analysis of AIPD patients showed that vitamine B12 (VB12) serum level (P=0.011, OR=0.995) and total cholesterol serum level (P=0.039, OR=1.874) were associated with the occurrence of AIPD. Conclusion · Patients with AIPD have psychiatric symptoms mainly consisting of hallucinations and delusions of murder. When patients’ laboratory tests show abnormal serum VB12 and serum total cholesterol levels, attentions should be paid to the occurrence of AIPD.

Key words: alcohol, psychotic disorder, vitamine B12 (VB12), clinical feature, risk factor

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