上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (11): 1519-1523.doi: 10.3969/j.issn.1674-8115.2020.11.015

• 综述 • 上一篇    下一篇

铁死亡相关机制与其在肝脏相关疾病中作用的研究进展

贺 明，魏 倩，张颖婷   

  1. 上海交通大学基础医学院病理生理学系，细胞分化与凋亡教育部重点实验室，上海200025
  • 出版日期:2020-11-28 发布日期:2021-01-13
  • 作者简介:贺 明（1980—），男，研究员，博士；电子信箱：heming@shsmu.edu.cn。
  • 基金资助:
    上海市自然科学基金（19ZR1428400）；国家自然科学基金（82070603，81470841，92057118）；上海交通大学医学院高水平地方高校创新团队（SSMU-ZDCX20180800）；上海交通大学医学院青年科技创新工作室资助项目（JYKCGZS15）。

Research progress in the mechanism of ferroptosis and its role in liver related diseases

HE Ming, WEI Qian, ZHANG Ying-ting   

  1. Key Laboratory for Cell Differentiation and Apoptosis, Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University College of Basic Medical Sciences, Shanghai 200025, China
  • Online:2020-11-28 Published:2021-01-13
  • Supported by:
    Natural Science Foundation of Shanghai (19ZR1428400); National Natural Science Foundation of China (82070603, 81470841, 92057118); Innovative Research Team of High-Level Local Universities in Shanghai (SSMU-ZDCX20180800); Supported by Youth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine (JYKCGZS15).

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摘要： 铁死亡（ferroptosis）是一种由铁依赖性的脂质过氧化引起的细胞死亡。在正常状态下，谷胱甘肽过氧化物酶4（glutathione peroxidase 4，GPX4）可通过将脂质过氧化物转化为无毒的脂质醇以防止铁死亡的发生。近来有研究证明，肝细胞铁死亡是酒精性脂肪肝等多种肝脏疾病的诱导和加重因素之一，而通过抑制GPX4来诱导肿瘤细胞发生铁死亡可能成为治疗肝癌的一种新策略。该文就铁死亡的分子机制及其在肝脏相关疾病中的作用进行综述，以期为肝脏疾病的治疗提供新的研究方向和思路。

关键词: 铁死亡, 肝脏疾病, 脂质过氧化, 谷胱甘肽过氧化物酶4, 肝癌

Abstract:

Ferroptosis is a type of cell death caused by iron-dependent lipid peroxidation. Glutathione peroxidase 4 (GPX4) can prevent ferroptosis by converting lipid peroxides into nontoxic lipid alcohols under normal condition. However, recent studies have shown that ferroptosis in hepatocytes is one of the factors that induce and aggravate various liver diseases such as alcoholic fatty liver disease. Thereby, inducing ferroptosis of cancer cells by inhibiting GPX4 may be a new strategy for the treatment of liver cancer. This article reviews the molecular mechanism of ferroptosis and its role in liver related diseases, in order to provide new research directions and ideas for the treatment of liver diseases.

Key words: ferroptosis, liver disease, lipid peroxidation, glutathione peroxidase 4 (GPX4), liver cancer

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