上海交通大学学报(医学版) ›› 2021, Vol. 41 ›› Issue (7): 972-976.doi: 10.3969/j.issn.1674-8115.2021.07.021

• 综述 • 上一篇    

精神分裂症患者骨代谢影响因素的研究进展

轩红艳1,2(), 王丽华1, 李华芳1,3,4()   

  1. 1.上海交通大学医学院附属精神卫生中心,上海 200030
    2.上海市长宁区精神卫生中心精神科,上海 200335
    3.上海市重性精神病重点实验室,上海 200030
    4.上海市精神心理疾病临床医学研究中心,上海 200030
  • 出版日期:2021-07-28 发布日期:2021-08-03
  • 通讯作者: 李华芳 E-mail:ameliexuan@163.com;lhlh_5@163.com
  • 作者简介:轩红艳(1989—),女,主治医师,硕士生;电子信箱:ameliexuan@163.com
  • 基金资助:
    上海市精神心理疾病临床医学研究中心(19MC1911100);上海市卫生和计划生育委员会项目(201740089)

Review of the factors influencing bone metabolism in schizophrenia

Hong-yan XUAN1,2(), Li-hua WANG1, Hua-fang LI1,3,4()   

  1. 1.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
    2.Department of Psychiatry, Shanghai Changning Mental Health Center, Shanghai 200335, China
    3.Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, China
    4.Shanghai Clinical Research Center for Mental Health, Shanghai 200030, China
  • Online:2021-07-28 Published:2021-08-03
  • Contact: Hua-fang LI E-mail:ameliexuan@163.com;lhlh_5@163.com
  • Supported by:
    Shanghai Clinical Research Center for Mental Health(19MC1911100);Project of Shanghai Municipal Commission of Health and Family Planning(201740089)

摘要:

精神分裂症患者与普通人群相比发生低骨密度、骨质疏松和骨折的风险更高,这不仅影响了患者的生活质量,而且影响其长期结局。既往研究表明,影响个体骨代谢的因素有很多,包括药物、性别、年龄、性腺功能和生活方式等。该文结合临床研究,从疾病本身、使用抗精神病药物及不良的生活方式3个方面进行综述,探讨了精神分裂症患者骨代谢可能的影响因素,并简单阐述了骨质疏松的诊断和干预措施,为临床预防和干预精神分裂症患者的骨质疏松提供依据。

关键词: 精神分裂症, 骨质疏松, 骨代谢, 抗精神病药物

Abstract:

The patients with schizophrenia experience a higher rate of low bone mineral density, osteoporosis and fractures than the general population, which affects not only their quality of life but also their long-term outcomes. Previous studies have shown that there are many factors affecting individual bone metabolism, including drugs, gender, age, hypogonadism, lifestyle, etc. Combined with clinical research, this article summarizes three aspects, i.e.,the disease itself, the use of antipsychotics and the unhealthy lifestyle. This review aims to discuss the influencing factors of bone metabolism in the patients with schizophrenia, and then expound briefly on the diagnosis and intervention measures of osteoporosis, which may provide a reference for clinical prevention and intervention of osteoporosis in the patients with schizophrenia.

Key words: schizophrenia, osteoporosis, bone metabolism, antipsychotics

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