上海交通大学学报(医学版) ›› 2023, Vol. 43 ›› Issue (4): 466-473.doi: 10.3969/j.issn.1674-8115.2023.04.009
• 论著 · 循证医学 • 上一篇
马卓然1,2(), 袁安彩2, 蒋惠如2, 陈潇雨3, 张薇2(
), 卜军2(
)
收稿日期:
2022-10-25
接受日期:
2023-03-14
出版日期:
2023-04-28
发布日期:
2023-04-28
通讯作者:
张薇,卜军
E-mail:asd3ggb@qq.com;zhangwei050080@renji.com;pujun310@hotmail.com
作者简介:
马卓然(1998—),女,硕士生;电子信箱:asd3ggb@qq.com。
基金资助:
MA Zhuoran1,2(), YUAN Ancai2, JIANG Huiru2, CHEN Xiaoyu3, ZHANG Wei2(
), PU Jun2(
)
Received:
2022-10-25
Accepted:
2023-03-14
Online:
2023-04-28
Published:
2023-04-28
Contact:
ZHANG Wei,PU Jun
E-mail:asd3ggb@qq.com;zhangwei050080@renji.com;pujun310@hotmail.com
Supported by:
摘要:
目的·探讨脂质蓄积指数(lipid accumulation product,LAP)与中国成年人高血压的关系。方法·通过检索英文数据库PubMed、Web of Science,中文数据库中国知网、万方数据知识服务平台,搜集从建库到2022年8月中国成年人LAP与高血压相关研究。由2位研究人员根据纳入和排除标准分别独立地对所有检索到的文献进行筛选,并使用JBI(Joanna Briggs Institute)诊断性研究量表对研究人群选择、可比性、暴露评价和结果等方面进行文献质量评估。对纳入的文献提取样本量、性别、灵敏度、特异度等信息,并使用Stata 16.0软件进行meta分析。结果·共纳入6篇文献,其中英文文献5篇,中文文献1篇。纳入文献的JBI偏倚评分为14~17分,均大于总分的70%,认为偏倚较小。纳入样本总数48 329例,其中高血压患者15 746例。Meta分析结果显示,在总人群中,LAP预测高血压的灵敏度为0.50(95%CI 0.35~0.64),特异度为0.78(95%CI 0.66~0.86);在女性中灵敏度为0.48(95%CI 0.32~0.64),特异度为0.77(95%CI 0.64~0.86);在男性中灵敏度为0.56(95%CI 0.39~0.72),特异度为0.64(95%CI 0.49~0.77)。纳入的总体人群综合受试者操作特征曲线(summary receiver operator characteristic curve,SROC曲线)下面积为0.70(95%CI 0.66~0.74),表明LAP和高血压存在一定的相关性。结论·在中国成年人群中,LAP与高血压有一定关联性。
中图分类号:
马卓然, 袁安彩, 蒋惠如, 陈潇雨, 张薇, 卜军. 脂质蓄积指数与中国成年人高血压关系的meta分析[J]. 上海交通大学学报(医学版), 2023, 43(4): 466-473.
MA Zhuoran, YUAN Ancai, JIANG Huiru, CHEN Xiaoyu, ZHANG Wei, PU Jun. Meta analysis of correlation between lipid accumulation product and hypertension in Chinese adults[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(4): 466-473.
The first author | Research area | Study time | Hypertension definition | Research type | Total sample size | Number of patients with hypertension | Quality score/point |
---|---|---|---|---|---|---|---|
YAN | Pudong New Area, Shanghai | January, 2012‒March, 2013 | Systolic blood pressure (SBP) ≥ 140 mmHg, diastolic blood pressure (DBP) ≥ 90 mmHg, or a history of oral antihypertensive medication | Cross-sectional study | 2 092 | 1 066 | 15 |
SONG | Bengbu, Anhui Province | 2018 | SBP≥140 mmHg, DBP≥90 mmHg, or the subject reported with a medical history of antihypertensive medication | Cross-sectional study | 1 777 | 433 | 14 |
Liaoning Province | 2012 | Blood pressure level of at least 140/90 mmHg, individuals who were on antihypertensive medications or a prior diagnosis of hypertension | Cross-sectional study | 11 400 | 5 684 | 17 | |
Foshan, Fujian Province | 2017 | Prehypertension was defined as SBP 120‒139 mmHg and/or DBP 80‒89 mmHg, and hypertension was defined as SBP≥140 mmHg, DBP≥90 mmHg and/or a reported medical history of antihypertensive medication | Cross-sectional study | 1 681 | 458 | 17 | |
LEE | The Taiwan region | 2022 | Hypertension was defined as a self-reported history, SBP≥140 mmHg, or DBP≥90 mmHg during follow-up | Cohort study | 21 466 | 3 157 | 16 |
LUO | Dalian, Liaoning Province | 2011 | Blood pressure≥140/90 mmHg and/or persons with confirmed hypertension and receiving treatment | Cross-sectional study | 9 913 | 4 948 | 14 |
表 1 纳入文献基本情况及质量评分
Tab 1 Basic information and quality score of included literature
The first author | Research area | Study time | Hypertension definition | Research type | Total sample size | Number of patients with hypertension | Quality score/point |
---|---|---|---|---|---|---|---|
YAN | Pudong New Area, Shanghai | January, 2012‒March, 2013 | Systolic blood pressure (SBP) ≥ 140 mmHg, diastolic blood pressure (DBP) ≥ 90 mmHg, or a history of oral antihypertensive medication | Cross-sectional study | 2 092 | 1 066 | 15 |
SONG | Bengbu, Anhui Province | 2018 | SBP≥140 mmHg, DBP≥90 mmHg, or the subject reported with a medical history of antihypertensive medication | Cross-sectional study | 1 777 | 433 | 14 |
Liaoning Province | 2012 | Blood pressure level of at least 140/90 mmHg, individuals who were on antihypertensive medications or a prior diagnosis of hypertension | Cross-sectional study | 11 400 | 5 684 | 17 | |
Foshan, Fujian Province | 2017 | Prehypertension was defined as SBP 120‒139 mmHg and/or DBP 80‒89 mmHg, and hypertension was defined as SBP≥140 mmHg, DBP≥90 mmHg and/or a reported medical history of antihypertensive medication | Cross-sectional study | 1 681 | 458 | 17 | |
LEE | The Taiwan region | 2022 | Hypertension was defined as a self-reported history, SBP≥140 mmHg, or DBP≥90 mmHg during follow-up | Cohort study | 21 466 | 3 157 | 16 |
LUO | Dalian, Liaoning Province | 2011 | Blood pressure≥140/90 mmHg and/or persons with confirmed hypertension and receiving treatment | Cross-sectional study | 9 913 | 4 948 | 14 |
图3 LAP预测中国成年人高血压能力的meta分析森林图Note: A. Total population included. B. Females included. C. Males included.
Fig 3 Meta-analysis forest chart of the ability of LAP to predict hypertension in Chinese adults
图4 LAP预测中国成年人高血压能力的SROC曲线Note: A. Total population included. B. Females included. C. Males included.
Fig 4 SROC curves of LAP predicting hypertension ability in Chinese adults
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