上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (5): 604-.doi: 10.3969/j.issn.1674-8115.2011.05.017

• 论著（临床研究） • 上一篇    下一篇

IDO和FoxP3表达与宫颈癌发生和病理进程的相关性

顾卓伟1, 狄 文1, 叶薇怡2, 王 颖2   

  1. 1.上海交通大学 医学院附属仁济医院妇产科上海市妇科肿瘤重点实验室, 上海 200127； 2.上海交通大学 基础医学院 |上海市免疫学研究所, 上海 200025
  • 出版日期:2011-05-28 发布日期:2011-05-27
  • 通讯作者: 王 颖, 电子信箱: ywang@sibs.ac.cn。
  • 作者简介:顾卓伟（1980—）, 男, 硕士生；电子信箱: gzw19801224@sina.com。
  • 基金资助:

    上海市教委基金（J50207）

Correlation of expression of IDO and FoxP3 with progression and prognosis of cervical cancer

GU Zhuo-wei1, DI Wen1, YE Wei-yi2, WANG Ying2   

  1. 1.Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China；2.Shanghai Institute of Immunology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2011-05-28 Published:2011-05-27
  • Supported by:

    Shanghai Education Committee Foundation, J50207

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摘要：

目的 探讨吲哚胺2，3-双加氧酶（IDO）和FoxP3表达与宫颈癌发生和病理进程的相关性。方法 随机选取2002—2007年在仁济医院妇产科手术治疗的患者标本，包括宫颈上皮内瘤变(CIN)Ⅰ~Ⅱ级20例(CINⅠ~Ⅱ级组)，CIN Ⅲ级20例(CIN Ⅲ级组)，宫颈癌60例(宫颈癌组)，因子宫肌瘤接受全子宫切除术且术后病理明确为子宫肌瘤的标本20例（对照组），采用免疫组织化学染色检测 IDO、FoxP3在CIN及宫颈癌原发灶中的表达。随访宫颈癌组标本中IDO和FoxP3表达与临床病理学参数及患者生存状态的相关性。结果 宫颈癌组标本的IDO和FoxP3阳性表达明显高于对照组和CIN组（P<0.01）。在宫颈癌组，IDO的阳性表达与宫颈癌的FIGO分期和组织学分级均相关（P<0.05），而FoxP3的阳性表达与FIGO分期相关（P<0.05）；IDO和FoxP3在复发与死亡组中的阳性表达率高于生存组，但两者间差异无统计学意义（P>0.05）。结论 宫颈癌局部IDO和FoxP3的表达升高与肿瘤的发生和发展关系密切，两者既可作为宫颈癌的筛查、术前疾病评估和术后随访的辅助指标，也为临床靶向干预提供了理论依据。

关键词: 宫颈癌, 宫颈上皮内瘤变, 吲哚胺2,3-双加氧酶, FoxP3

Abstract:

Objective To investigate the correlation of expression of indoleamine 2,3-dioxygenase(IDO) and FoxP3 with progression and prognosis of cervical cancer. Methods Twenty cases of cervical intraepithelial neoplasia(CIN) Ⅰ-Ⅱ grade (CINⅠ-Ⅱ grade group), 20 cases of CIN Ⅲ grade (CIN Ⅲ grade group) and 60 cases of cervical cancer (cervical cancer group) were selected, and 20 cases of uterine myoma were served as control group. The expression of IDO and FoxP3 in CIN and cervical cancer lesions was detected by immunohistochemistry. Patients were followed up for prognostic indicators. Results The expression of IDO and FoxP3 in cervical cancer group was significantly higher than that in control group and CIN groups (P<0.01). In cervical cancer group, the expression of IDO was related to both FIGO stage and histological grade of cervical cancer (P<0.05), the expression of FoxP3 was related to FIGO stage (P<0.05), and the expression of IDO and FoxP3 in recurrence and death group was higher than that in survival group, with no significant difference between them (P>0.05). Conclusion The increased expression of IDO and FoxP3 in local lesions of cervical cancer is closely related to the occurrence and progression of the disease, which may serve as adjuvant indicators for screening, preoperative evaluation and postoperative follow-up of cervical cancer, as well as theory basis for therapeutic targets of cervical cancer.

Key words: cervical cancer, cervical intraepithelial neoplasia, indoleamine 2,3-dioxygenase, FoxP3