›› 2011, Vol. 31 ›› Issue (6): 858-.doi: 10.3969/j.issn.1674-8115.2011.06.040

• 综述 • 上一篇    下一篇

细胞色素P450 4F2基因多态性的研究进展

李劼慧, 徐建军   

  1. 南昌大学 |第二附属医院心胸外科, 南昌 330006
  • 出版日期:2011-06-28 发布日期:2011-06-27
  • 通讯作者: 徐建军, 电子信箱: xujianjun3526@163.com。
  • 作者简介:李劼慧(1983—), 男, 主治医师, 硕士;电子信箱: lijiehuimail@qq.com。

Research progress of single nucleotide polymorphisms of cytochrome P450 4F2

LI Jie-hui, XU Jian-jun   

  1. The Second Affiliated Hospital to Nanchang University, Nanchang 330006, China
  • Online:2011-06-28 Published:2011-06-27

摘要:

细胞色素P450(CYP)4F2是CYP的亚型,参与体内一系列生化反应。新近的研究发现了它在心脑血管及血液学领域等方面新的生理机制,由此可以从多个角度全新解释相关领域的疾病及病理生理过程,如原发性高血压、心肌梗死、脑卒中及脂类物质花生四烯酸和药物华法林等在体内的代谢等。

关键词: 细胞色素P450, 基因多态性, 病理生理

Abstract:

Cytochrome P450 (CYP) 4F2, a member of the CYP4F enzyme subfamily, takes part in a series of biochemical reaction in vivo. Recent researches have revealed the new mechanism the enzyme plays in the cardiovascular and hematological fields, such as essential hypertension, myocardial infarction, stroke and metabolism of arachidonic acid and warfarin.

Key words: cytochrome P450, single nucleotide polymorphisms, pathophysiology