上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (10): 1489-.doi: 10.3969/j.issn.1674-8115.2011.10.029

• 短篇论著 • 上一篇    下一篇

还原型谷胱甘肽对老年急性脑梗死患者血浆C反应蛋白的影响

汤政德, 宋 涛, 苏海霞   

  1. 上海交通大学 |医学院附属第九人民医院心肺功能科, 上海 200011
  • 出版日期:2011-10-28 发布日期:2011-10-27
  • 作者简介:汤政德（1976—）, 男, 硕士生；电子信箱: tzdxixi@sina.com。

Effects of reduced glutathione on plasma levels of C-reactive protein in elderly patients with acute cerebral infarction

TANG Zheng-de, SONG Tao, SU Hai-xia   

  1. Department of Cardiopulmonary Function, the Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
  • Online:2011-10-28 Published:2011-10-27

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摘要：

目的 观察还原型谷胱甘肽对老年脑梗死患者血浆C反应蛋白（CRP）的影响。方法 将60例确诊的急性脑梗死老年患者，根据治疗方式分为治疗组和对照组，每组30例。对照组给予常规抗血小板、活血化淤、改善脑细胞功能以及控制基础疾病治疗；治疗组在常规治疗基础上加用还原型谷胱甘肽（1.8 g/d），两组疗程均为14 d。ELISA法检测两组患者治疗前后的血浆CRP的质量浓度。结果 治疗组和对照组患者治疗后血浆CRP的质量浓度均较治疗前显著降低[（19.9±2.0）mg/L和（47.0±5.7）mg/L，P<0.01；（28.5±4.1）mg/L和（43.3±5.2）mg/L，P＜0.05]；且治疗组较对照组下降程度更大[（29.5±5.7）mg/L和（14.1±3.0）mg/L，P<0.01]。结论 还原型谷胱甘肽可显著降低老年脑梗死患者的血浆CRP浓度，具有抑制炎症反应、拮抗氧自由基对血管损伤的功能，值得在临床上推广应用。

关键词: 脑梗死, C反应蛋白, 还原型谷胱甘肽, 炎症, 氧自由基

Abstract:

Objective To observe the effects of reduced glutathione on plasma levels of C-reactive protein (CRP) in elderly patients with acute cerebral infarction. Methods Sixty patients with acute cerebral infarction were divided into treatment group and control group, with 30 patients in each group. Patients in control group received routine therapy including anti-platelet, invigorating blood circulation and eliminating stasis, improving brain cell function and control basic diseases. Patients in treatment group received reduced glutathione (1.8 g/d) in addition to routine therapy. The course of treatment in both groups was 14 d. Plasma concentrations of CRP before and after treatment in both groups were measured by ELISA. Results The plasma concentrations of CRP in treatment group and control group after treatment were significantly lower than those before treatment [(19.9±2.0) mg/L vs (47.0±5.7) mg/L，P<0.01；（28.5±4.1）mg/L vs (43.3±5.2) mg/L，P＜0.05]. The decrease of plasma concentrations of CRP in treatment group was more significant than that in control group [（29.5±5.7）mg/L vs （14.1±3.0）mg/L，P<0.01]. Conclusion Reduced glutathione, which has the antiinflammation and anti-oxidation effects, can significantly decrease the plasma concentrations of CRP in elderly patients with acute cerebral infarction.

Key words: cerebral infarction, C-reactive protein, reduced glutathione, inflammation, oxygen radical