上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (12): 1729-.doi: 10.3969/j.issn.1674-8115.2011.12.015

• 论著（临床研究） • 上一篇    下一篇

布地奈德混悬液联合妥洛特罗贴剂治疗婴幼儿反复喘息的疗效及安全性研究

朱亚菊, 林 芊, 华 丽, 鲍一笑   

  1. 上海交通大学 医学院附属新华医院儿童呼吸科, 上海 200092
  • 出版日期:2011-12-28 发布日期:2012-01-04
  • 通讯作者: 鲍一笑, 电子信箱: dr.smilebao@yahoo.com.cn。
  • 作者简介:朱亚菊（1986—）, 女, 硕士生；电子信箱: zyj0442058@126.com。
  • 基金资助:

    上海市科委生物医学重点基金（08411953200）；上海市科委生物医药重大基金（10DZ1951000）

Efficacy and safety of budesonide suspension fluid combined with tulobuterol tape in treatment of recurrent wheezing in infants and young children

ZHU Ya-ju, LIN Qian, HUA Li, BAO Yi-xiao   

  1. Department of Pediatric Pneumology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2011-12-28 Published:2012-01-04
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 08411953200, 10DZ1951000

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摘要：

目的 探讨布地奈德混悬液雾化吸入和妥洛特罗贴剂联合治疗婴幼儿反复喘息的疗效及安全性。方法 选取反复喘息婴幼儿62例，随机分为试验组（n=31）和对照组（n=31）。在喘息临床缓解后稳定期的控制阶段，试验组给予雾化吸入布地奈德混悬液联合妥洛特罗贴剂共12周；对照组给予雾化吸入布地奈德混悬液12周。分别在2、4、6、8、10、12周进行随访，分析患儿咳喘发作、呼吸道感染次数及合并用药情况。结果 试验组30例及对照组29例患儿完成了12周的既定治疗方案及随访。试验组咳嗽症状评分、喘息发作次数、喘息症状评分、合并用药评分均低于对照组，差异均有统计学意义（P＜0.01）；试验组呼吸道感染次数明显少于对照组（P＜0.05）。结论 布地奈德混悬液雾化吸入和妥洛特罗贴剂联合治疗婴幼儿反复喘息的疗效优于单用布地奈德雾化吸入，且安全性较高。

关键词: 婴幼儿喘息, 妥洛特罗贴剂, 布地奈德混悬液

Abstract:

Objective To evaluate the efficacy and safety of budesonide suspension fluid inhalation combined with tulobuterol tape in treatment of recurrent wheezing in infants and young children. Methods Sixty-two infants and young children with recurrent wheezing were randomly divided into  treatment group (n=31) and control group (n=31). When wheezing was relieved, patients in  treatment  group were treated with budesonide suspension fluid inhalation combined with tulobuterol tape for 12 weeks, while those in control group were treated with  budesonide suspension fluid inhalation only. Patients were followed up during the 2nd, 4th, 6th, 8th, 10th and 12th week, and the frequencies of cough and respiratory tract infection and the condition of combination use of drugs were analysed. Results Thirty patients in  treatment group and 29 patients in control group completed the treatment and follow up. The scoring of cough, frequency of wheezing, scoring of wheezing and scoring of combination use of drugs in  treatment group were significantly lower than those in control group (P＜0.01), and the frequency of respiratory tract infection in  treatment group was significantly lower than that in control group (P＜0.05). Conclusion Budesonide suspension fluid inhalation combined with tulobuterol tape is more effective and safe than budesonide suspension fluid inhalation only in treatment of recurrent wheezing in infants and young children.

Key words: wheezing in infants and young children, tulobuterol tape, budesonide suspension fluid