Journal of Shanghai Jiao Tong University (Medical Science) ›› 2023, Vol. 43 ›› Issue (6): 680-688.doi: 10.3969/j.issn.1674-8115.2023.06.004
• Pediatric asthma column • Previous Articles
DANG Xiangyang(), TANG Yuyi, LI Weiguo, LIU Enmei()
Received:
2022-12-05
Accepted:
2023-05-17
Online:
2023-06-28
Published:
2023-06-28
Contact:
LIU Enmei
E-mail:dxy91512@163.com;emliu186@126.com
CLC Number:
DANG Xiangyang, TANG Yuyi, LI Weiguo, LIU Enmei. Diagnostic value of fractional exhaled nitric oxide in predicting cough variant asthma in children with chronic cough: a systematic review and meta-analysis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(6): 680-688.
Add to citation manager EndNote|Ris|BibTeX
URL: https://xuebao.shsmu.edu.cn/EN/10.3969/j.issn.1674-8115.2023.06.004
Study | Country | Design | Sample size (CVA/nCVA) | Age/year | Cut-off value/ppb | FeNO measurement | Diagnostic criterion for CVA | FeNO test | |||
---|---|---|---|---|---|---|---|---|---|---|---|
TP/n | FP/n | FN/n | TN/n | ||||||||
JI et al, 2013[ | China | Retrospective | 42/44 | 5‒14 | 22.5 | NIOX MINO (Aerocrine, Sweden) | Chinese guideline for diagnosis and treatment of chronic cough in pediatrics (2008 version)[ | 37 | 4 | 7 | 38 |
CAO et al, 2015[ | China | Prospective | 81/127 | 0‒12 | 36 | Nano Coulomb Nitric Oxide Analyzer (Sunvou Medical Electronics Co., Ltd., China) | Chinese guideline for diagnosis and treatment of chronic cough in pediatrics (2008 version)[ | 68 | 4 | 13 | 123 |
ZHU et al, 2015[ | China | Prospective | 38/46 | 6‒12 | 25.5 | NIOX MINO (Aerocrine, Sweden) | Chinese guideline for diagnosis and treatment of chronic cough in pediatrics (2008 version)[ | 47 | 8 | 10 | 71 |
NIU et al, 2016[ | China | Prospective | 106/68 | 6‒14 | 20.5 | Nano Coulomb Nitric Oxide Analyzer (Sunvou Medical Electronics Co., Ltd., China) | Guideline for diagnosis and treatment of chronic cough in Chinese pediatrics (2013 version)[ | 79 | 9 | 27 | 59 |
ZHOU et al, 2018[ | China | Prospective | 53/62 | 6‒14 | 25 | NIOX MINO (Aerocrine, Sweden) | ACCP evidence-based clinical practice guideline (2006 version)[ | 45 | 2 | 8 | 60 |
YILDIZ et al, 2018[ | Turkey | Retrospective | 27/63 | 6‒17 | 24 | NIOX MINO (Aerocrine, Sweden) | ACCP evidence-based clinical practice guideline (2006 version)[ | 21 | 5 | 6 | 58 |
ZHOU et al, 2018[ | China | Retrospective | 41/65 | 6‒13 | 27.64 | NIOX MINO (Aerocrine, Sweden) | Guideline for diagnosis and treatment of chronic cough in Chinese pediatrics (2013 version)[ | 36 | 10 | 5 | 55 |
LI et al, 2018[ | China | Retrospective | 43/65 | 0‒12 | 35 | NIOX MINO (Aerocrine, Sweden) | Chinese guideline for diagnosis and treatment of chronic cough in pediatrics (2008 version)[ | 36 | 2 | 7 | 63 |
ZHU et al, 2019[ | China | Prospective | 57/79 | 6‒12 | 25.5 | NIOX MINO (Aerocrine, Sweden) | Guideline for diagnosis and treatment of chronic cough in Chinese pediatrics (2013 version)[ | 47 | 8 | 10 | 71 |
Tab 1 FeNO levels of the CVA group and other children with chronic cough
Study | Country | Design | Sample size (CVA/nCVA) | Age/year | Cut-off value/ppb | FeNO measurement | Diagnostic criterion for CVA | FeNO test | |||
---|---|---|---|---|---|---|---|---|---|---|---|
TP/n | FP/n | FN/n | TN/n | ||||||||
JI et al, 2013[ | China | Retrospective | 42/44 | 5‒14 | 22.5 | NIOX MINO (Aerocrine, Sweden) | Chinese guideline for diagnosis and treatment of chronic cough in pediatrics (2008 version)[ | 37 | 4 | 7 | 38 |
CAO et al, 2015[ | China | Prospective | 81/127 | 0‒12 | 36 | Nano Coulomb Nitric Oxide Analyzer (Sunvou Medical Electronics Co., Ltd., China) | Chinese guideline for diagnosis and treatment of chronic cough in pediatrics (2008 version)[ | 68 | 4 | 13 | 123 |
ZHU et al, 2015[ | China | Prospective | 38/46 | 6‒12 | 25.5 | NIOX MINO (Aerocrine, Sweden) | Chinese guideline for diagnosis and treatment of chronic cough in pediatrics (2008 version)[ | 47 | 8 | 10 | 71 |
NIU et al, 2016[ | China | Prospective | 106/68 | 6‒14 | 20.5 | Nano Coulomb Nitric Oxide Analyzer (Sunvou Medical Electronics Co., Ltd., China) | Guideline for diagnosis and treatment of chronic cough in Chinese pediatrics (2013 version)[ | 79 | 9 | 27 | 59 |
ZHOU et al, 2018[ | China | Prospective | 53/62 | 6‒14 | 25 | NIOX MINO (Aerocrine, Sweden) | ACCP evidence-based clinical practice guideline (2006 version)[ | 45 | 2 | 8 | 60 |
YILDIZ et al, 2018[ | Turkey | Retrospective | 27/63 | 6‒17 | 24 | NIOX MINO (Aerocrine, Sweden) | ACCP evidence-based clinical practice guideline (2006 version)[ | 21 | 5 | 6 | 58 |
ZHOU et al, 2018[ | China | Retrospective | 41/65 | 6‒13 | 27.64 | NIOX MINO (Aerocrine, Sweden) | Guideline for diagnosis and treatment of chronic cough in Chinese pediatrics (2013 version)[ | 36 | 10 | 5 | 55 |
LI et al, 2018[ | China | Retrospective | 43/65 | 0‒12 | 35 | NIOX MINO (Aerocrine, Sweden) | Chinese guideline for diagnosis and treatment of chronic cough in pediatrics (2008 version)[ | 36 | 2 | 7 | 63 |
ZHU et al, 2019[ | China | Prospective | 57/79 | 6‒12 | 25.5 | NIOX MINO (Aerocrine, Sweden) | Guideline for diagnosis and treatment of chronic cough in Chinese pediatrics (2013 version)[ | 47 | 8 | 10 | 71 |
1 | MARCHANT J M, NEWCOMBE P A, JUNIPER E F, et al. What is the burden of chronic cough for families?[J]. Chest, 2008, 134(2): 303-309. |
2 | CHANG A B, OPPENHEIMER J J, WEINBERGER M, et al. Etiologies of chronic cough in pediatric cohorts: chest guideline and expert panel report[J]. Chest, 2017, 152(3): 607-617. |
3 | 中华医学会儿科学分会临床药理学组, 国家儿童健康与疾病临床医学研究中心, 中华医学会儿科学分会呼吸学组, 等. 中国儿童咳嗽诊断与治疗临床实践指南(2021版)[J]. 中华儿科杂志, 2021, 59(9): 720-729. |
The Subspecialty Group of Pharmacology, the Society of Pediatrics, Chinese Medical Association, National Clinical Research Center for Child Health and Disorders, the Subspecialty Group of Respiratory Diseases, the Society of Pediatrics, Chinese Medical Association, et al. Clinical practice guidelines for the diagnosis and management of children with cough in China (version 2021)[J]. Chinese Journal of Pediatrics, 2021, 59(9): 720-729. | |
4 | CHANG A B, OPPENHEIMER J J, IRWIN R S, et al. Managing chronic cough as a symptom in children and management algorithms: chest guideline and expert panel report[J]. Chest, 2020, 158(1): 303-329. |
5 | SONG D J, SONG W J, KWON J W, et al. KAAACI evidence-based clinical practice guidelines for chronic cough in adults and children in Korea[J]. Allergy Asthma Immunol Res, 2018, 10(6): 591-613. |
6 | MORICE A H, MILLQVIST E, BIEKSIENE K, et al. ERS guidelines on the diagnosis and treatment of chronic cough in adults and children[J]. Eur Respir J, 2020, 55(1): 1901136. |
7 | 中国儿童慢性咳嗽病因构成比研究协作组. 中国儿童慢性咳嗽病因构成比多中心研究[J]. 中华儿科杂志, 2012, 50(2): 83-92. |
Clinical Research Coordination Group of the Causes Constituents Ratio of Chronic Cough in Chinese Children. Prospective multicenter clinical study on the causes constituents ratio of chronic cough in Chinese children[J]. Chinese Journal of Pediatrics, 2012, 50(2): 83-92. | |
8 | CHEN X, PENG W S, WANG L. Etiology analysis of nonspecific chronic cough in children of 5 years and younger[J]. Medicine (Baltimore), 2019, 98(3): e13910. |
9 | LAI K F, CHEN R C, LIN J T, et al. A prospective, multicenter survey on causes of chronic cough in China[J]. Chest, 2013, 143(3): 613-620. |
10 | ZHOU X L, ZHANG Y, LIU L, et al. Therapeutic effect of acupuncture combined montelukast sodium on cough variant asthma in children: a protocol for systematic review and meta-analysis[J]. Medicine (Baltimore), 2021, 100(51): e28048. |
11 | FUJIMURA M, OGAWA H, NISHIZAWA Y, et al. Comparison of atopic cough with cough variant asthma: is atopic cough a precursor of asthma?[J]. Thorax, 2003, 58(1): 14-18. |
12 | MANISCALCO M, FUSCHILLO S, GAUDIOSI C, et al. Exhaled and nasal nitric oxide measurement in the evaluation of chronic cough[J]. Nitric Oxide, 2019, 83: 19-23. |
13 | 中华医学会儿科学分会呼吸学组哮喘协作组. 儿童呼出气一氧化氮检测及临床应用专家共识(2021版)[J]. 中华实用儿科临床杂志, 2021, 36(6): 417-423. |
Collaboration Group of Asthma, the Subspecialty Group of Respiratory Diseases, the Society of Pediatrics, Chinese Medical Association. Expert consensus on detection and clinical application of exhaled nitric oxide in children (2021 edition)[J]. Chinese Journal of Applied Clinical Pediatrics, 2021, 36(6): 417-423. | |
14 | 王芷婧, 王淼, 王圣元, 等. FeNO检测对中国人群激素敏感性咳嗽诊断价值的meta分析[J]. 国际呼吸杂志, 2020, 40(5): 359-367. |
WANG Z J, WANG M, WANG S Y, et al. Diagnostic value of fractional exhaled nitric oxide test in corticosteroid responsive cough patients in China: a meta-analysis[J]. International Journal of Respiration, 2020, 40(5): 359-367. | |
15 | SONG W J, KIM H J, SHIM J S, et al. Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: a systematic review and meta-analysis[J]. J Allergy Clin Immunol, 2017, 140(3): 701-709. |
16 | 郭治, 王鑫, 邢国宏, 等. 呼出气一氧化氮检测对咳嗽变异型哮喘诊断价值的meta分析[J]. 国际呼吸杂志, 2015, 35(20): 1535-1540. |
GUO Z, WANG X, XING G H, et al. Fractional exhaled nitric oxide in cough variant asthma: a meta-analysis[J]. International Journal of Respiration, 2015, 35(20): 1535-1540. | |
17 | 张瑞, 陈如冲, 贾留群, 等. 呼出气一氧化氮对慢性咳嗽人群中咳嗽变异型哮喘的诊断价值: meta分析[J]. 国际呼吸杂志, 2017, 37(16): 1201-1206. |
ZHANG R, CHEN R H, JIA L Q, et al. Diagnostic accuracy of fractional exhaled nitric oxide for cough variant asthma in chronic cough patients: a meta-analysis[J]. International Journal of Respiration, 2017, 37(16): 1201-1206. | |
18 | 中华医学会儿科学分会呼吸学组, 《中华儿科杂志》编辑委员会. 儿童慢性咳嗽诊断与治疗指南(试行)[J]. 中华儿科杂志, 2008, 46(2): 104-107. |
The Subspecialty Group of Respiratory Diseases, the Society of Pediatrics, Chinese Medical Association, Editorial Board of Chinese Journal of Pediatrics. Guideline for diagnosis and treatment of chronic cough in pediatrics[J]. Chinese Journal of Pediatrics, 2008, 46(2): 104-107. | |
19 | 中华医学会儿科学分会呼吸学组慢性咳嗽协作组, 《中华儿科杂志》编辑委员会. 中国儿童慢性咳嗽诊断与治疗指南(2013年修订)[J]. 中华儿科杂志, 2014, 52(3): 184-188. |
Collaboration Group of Chronic Cough, the Subspecialty Group of Respiratory Diseases, the Society of Pediatrics, Chinese Medical Association, Editorial Board of Chinese Journal of Pediatrics. Guideline for diagnosis and treatment of chronic cough in Chinese pediatrics (2013 version)[J]. Chinese Journal of Pediatrics, 2014, 52(3): 184-188. | |
20 | IRWIN R S, BAUMANN M H, BOLSER D C, et al. Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines[J]. Chest, 2006, 129(1 Suppl): 1S-23S. |
21 | WHITING P F, RUTJES A W, WESTWOOD M E, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies[J]. Ann Intern Med, 2011, 155(8): 529-536. |
22 | REITSMA J B, GLAS A S, RUTJES A W, et al. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews[J]. J Clin Epidemiol, 2005, 58(10): 982-990. |
23 | RUTTER C M, GATSONIS C A. A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations[J]. Stat Med, 2001, 20(19): 2865-2884. |
24 | 张天嵩, 李博, 钟文昭. 实用循证医学方法学[M]. 3版. 长沙: 中南大学出版社, 2021. |
ZHANG T S, LI B, ZHONG W Z. Applied Methodology for Evidence-based Medicine[M]. 3rd ed. Changsha: Central South University Press, 2021. | |
25 | 季秀梅, 王凯旋, 陈菊萍, 等. 慢性咳嗽儿童呼出气一氧化氮检测的临床意义[J]. 中国现代医生, 2013, 51(15): 39-41. |
JI X M, WANG K X, CHEN J P, et al. Clinical significance of fractional exhaled nitric oxide in children with chronic cough[J]. China Modern Doctor, 2013, 51(15): 39-41. | |
26 | 曹兴丽, 武怡. 呼出气一氧化氮在儿童咳嗽变异性哮喘诊断中的价值[J]. 徐州医学院学报, 2015, 35(5): 328-330. |
CAO X L, WU Y. Measurement of fractional nitric oxide concentration in exhaled breath to assess cough variant asthma in child patients[J]. Journal of Xuzhou Medical University, 2015, 35(5): 328-330. | |
27 | 朱海艳, 于兴梅, 郝创利, 等. 呼出气一氧化氮测定对儿童咳嗽变异性哮喘的诊断价值[J]. 中华结核和呼吸杂志, 2015, 38(5): 352-355. |
ZHU H Y, YU X M, HAO C L, et al. The diagnostic value of the fractional exhaled nitric oxide for cough variant asthma in children[J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2015, 38(5): 352-355. | |
28 | 牛文泽, 杜许芳, 孟柳明, 等. 呼出气一氧化氮检测在儿童咳嗽变异性哮喘中的诊疗价值[J]. 中国中西医结合儿科学, 2016, 8(3): 269-272. |
NIU W Z, DU X F, MENG L M, et al. Value of fractional exhaled nitric oxide in the diagnosis and treatment of children with cough variant asthma[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2016, 8(3): 269-272. | |
29 | ZHOU J, ZHAO X H, ZHANG X, et al. Values of fractional exhaled nitric oxide for cough-variant asthma in children with chronic cough[J]. J Thorac Dis, 2018, 10(12): 6616-6623. |
30 | YILDIZ Y, IGDE M. Evaluation of fractioned nitric oxide in chronic cough patients[J]. Niger J Clin Pract, 2018, 21(1): 1-6. |
31 | 周晓娜, 谭淑英. FeNO、FEV1/FVC%、BPT在小儿CVA诊断中的价值分析[J]. 临床肺科杂志, 2018, 23(6): 1048-1051. |
ZHOU X N, TAN S Y. Value of FeNO, FEV1/FVC% and BPT in diagnosis of children with CVA[J]. Journal of Clinical Pulmonary Medicine, 2018, 23(6): 1048-1051. | |
32 | 李卫兵. 呼出气一氧化氮检测对儿童咳嗽变异性哮喘的诊断价值[J]. 江苏医药, 2018, 44(2): 213-215. |
LI W B. Value of fractional exhaled nitric oxide in the diagnosis of children with cough variant asthma[J]. Jiangsu Medical Journal, 2018, 44(2): 213-215. | |
33 | ZHU H Y, ZHANG R R, HAO C L, et al. Fractional exhaled nitric oxide (FeNO) combined with pulmonary function parameters shows increased sensitivity and specificity for the diagnosis of cough variant asthma in children[J]. Med Sci Monit, 2019, 25: 3832-3838. |
34 | MUNAKATA M. Exhaled nitric oxide (FeNO) as a non-invasive marker of airway inflammation[J]. Allergol Int, 2012, 61(3): 365-372. |
35 | YI F, CHEN R C, LUO W, et al. Validity of fractional exhaled nitric oxide in diagnosis of corticosteroid-responsive cough[J]. Chest, 2016, 149(4): 1042-1051. |
36 | SONG W J, KWON J W, KIM E J, et al. Clinical application of exhaled nitric oxide measurements in a Korean population[J]. Allergy Asthma Immunol Res, 2015, 7(1): 3-13. |
37 | 中华医学会儿科学分会呼吸学组肺功能协作组, 《中华实用儿科临床杂志》编辑委员会. 儿童肺功能及气道非创伤性炎症指标系列指南(七): 呼出气体一氧化氮监测[J]. 中华实用儿科临床杂志, 2017, 32(21): 1622-1627. |
Collaboration Group of Pulmonary Function, the Subspecialty Group of Respiratory Diseases, the Society of Pediatrics, Chinese Medical Association, Editorial Board of Chinese Journal of Applied Clinical Pediatrics. Series guidelines for pediatric pulmonary function and non-invasive airway inflammation marker (part Ⅶ): fractional exhaled nitric oxide monitoring[J]. Chinese Journal of Applied Clinical Pediatrics, 2017, 32(21): 1622-1627. | |
38 | 王天玥, 尚云晓, 张晗. 呼出气一氧化氮浓度测定在儿童支气管哮喘和咳嗽变异性哮喘中的诊断价值[J]. 中国当代儿科杂志, 2015, 17(8): 800-805. |
WANG T Y, SHANG Y X, ZHANG H. Diagnostic values of fractional exhaled nitric oxide for typical bronchial asthma and cough variant asthma in children[J]. Chinese Journal of Contemporary Pediatrics, 2015, 17(8): 800-805. |
[1] | WEN Yajin, HE Wen, HAN Xiao, ZHANG Xiaobo. Exploratory analysis of gut microbiota differences in childhood asthma with different severity [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(6): 655-664. |
[2] | WANG Yingwen, LI Xiaoling, DAI Jiajia, LIU Fang, HUANG Jianfeng, WANG Libo, ZHANG Xiaobo, FENG Rui. Epidemiological characteristics and risk factors of severe asthma in children: a single-center prospective cohort study [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(6): 665-672. |
[3] | LI Pengyun, DAI Yinfang, LU Yanhong, YU Xingmei, XU Lina, DI Wujianfeng, HAO Chuangli. Clinical study of exhaled nitric oxide in children with asthma and allergic rhinitis [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(6): 673-679. |
[4] | XU Xiaojun, YE Minjie, WANG Yuchen, WANG Wenxia, QIAN Sheng, YE Dandi, PAN Lele, HU Xin, YIN Xiaoli, LI Meihua, LING Guangyao. A comparative study of prepulse inhibition in children with first episode schizophrenia and normal children [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(5): 606-610. |
[5] | LI Ying, TAN Yangxia, YIN Hongxin, JIANG Yanling, CHEN Li, MENG Guoyu. Research progress in the pathogenesis and prognosis of ZNF384 fusion subtype acute leukemia [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(5): 631-640. |
[6] | JIANG Jing, BIAN Yong, ZHENG Jijian, HUANG Yue. Factors influencing the amount of blood loss in pediatric patients during craniosynostosis surgery [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(4): 453-458. |
[7] | ZHU Siyu, DONG Xiaoyan. New insights in small airway dysfunction of childhood asthma [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(4): 500-506. |
[8] | RAO Lin, ZHANG Linna, YUAN Jiaqi, LU Bangchun. Effect of postpartum pelvic floor muscle training on improving pelvic floor function [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(3): 308-313. |
[9] | SHI Cuicui, ZHANG Jie, HUANG Heming, SANG Yuer, LI Guangming. Clinical analysis of insulin resistance in liver cirrhosis patients [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(2): 188-193. |
[10] | FENG Jiali, PENG Yu, DUAN Junkai. Progress in functional mechanisms and biomarkers of miRNA related to Kawasaki disease [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(2): 256-260. |
[11] | HOU Shumin, SHAO Jingbo. Research progress in clinical characteristics, diagnosis and prognosis of TdT-negative lymphoblastic lymphoma/acute lymphoblastic leukemia [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(1): 120-124. |
[12] | DENG Yuntian, XIONG Wenkui, ZHU Rui, LIU Enmei, LI Xuemei, ZHONG Zhaohui. A case-control study of the relationship between early-life environmental exposure and childhood asthma [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(1): 44-51. |
[13] | LUO Wenyi, CHEN Lin, YUAN Li, NI Ping, CAI Xiaoman, ZHANG Yaqing. Rasch analysis of postoperative cardiac rehabilitation and related factors in 3-6-year-old children with congenital heart disease [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(9): 1303-1310. |
[14] | LI Wen, LI Yuan, YE Haiyun, ZHANG Xiaoxiao, QIAO Tong, LI Pin. Observation on early microvascular changes in macular area of the fundus in children with type 1 diabetes mellitus [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(9): 1311-1314. |
[15] | ZHAO Qing, GU Wenjie, WANG Zhen. Mediating effects of neuroticism and immature defense on relationship between childhood trauma and obsessive-compulsive symptoms in patients with obsessive-compulsive disorder [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(9): 1315-1322. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||