Abstract:

Objective To evaluate the risk of trans fatty acids on coronary heart diseases by Meta-analysis. Methods Related literatures were searched with subject words including“trans fatty acids”, “sudden cardiac death”, “myocardial infarction” and “coronary heart disease” from electronic databases of Medline, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Chongqing VIP Database and Wanfang Data, etc. With multivariate adjusted relative ratio (RR) or odds ratio (OR) and their 95% confidence interval (CI) as parameters, literatures included were analysed by fixed effect model of Meta-analysis after heterogeneity inspection. Results A total of 9 literatures were selected, including 6 cohort studies and 3 case-control studies. Combined RR between trans fatty acids intake and coronary heart disease events and between trans fatty acids intake and fatal coronary heart diseases were 1.234 (95%CI 1.117-1.363, P=0.000) and 1.307 (95%CI 1.113-1.535, P=0.001)， respectively. Combined OR between trans fatty acids in subcutaneous fat and first myocardial infarction events was 1.560 (95%CI 1.119-2.175, P=0.009). Sensitivity analysis revealed that the results of this Meta-analysis were stable. Conclusion Trans fatty acids may be a risk factor for coronary heart diseases.

Key words: trans fatty acids, coronary heart disease, sudden cardiac death, myocardial infarction, Meta-analysis