Abstract:

Objective To assess the analgesic effects of propacetamol with fentanyl after lumbar spine surgery. Methods Sixty patients undergoing lumbar spine surgery were randomly divided into two groups, with 30 patients in each group. Patients in group Ⅰ were treated with 2 g propacetamol 15 min before the end of operation, and were managed with self-controlled analgesia (PCA) pump with fentanyl after operation. Patients in group Ⅱ were just given PCA pump with fentanyl after operation. PCA pumps were composed of fentanyl with 0.4 μg·kg^-1·h^-1, and were used for 48 h. The time of extubation after operation and the analgesia scores, sedation scores, respiration, circulation, vomiting at different time points within 48 h after operation in two groups were recorded. Results There was no significant difference in the time of extubation, and sedation scores, respiration, mean arterial pressure, heart rates and vomiting at different time points after operation between two groups (P>0.05). The analgesia scores in group Ⅰ were superior to those in group Ⅱ at the time points of 30 min, 1 h, 2 h, 4 h, 6 h and 12 h after operation （P<0.05）, while there was no significant difference in the analgesia scores between two groups at the other time points (P>0.05). Conclusion The analgesic effect of propacetamol with fentanyl after surgery is safe and effective.

Key words: propacetamol, fentanyl, analgesia, lumbar spine