›› 2019, Vol. 39 ›› Issue (10): 1178-.doi: 10.3969/j.issn.1674-8115.2019.10.013

• Original article (Clinical research) • Previous Articles     Next Articles

Expression and clinical significance of long-chain non-coding RNA lincRNA-BBOX1-2 in gastric cancer

SUN Ying1, HU Mei-jie2, GU Wei1, LI Jian1, WANG Ji1, ZHENG Xiong1   

  1. 1. Department of Gastroenterology, Luwan Branch, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China; 2. Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2019-10-28 Published:2019-11-22
  • Supported by:
    Scientific Research Project of Shanghai Municipal Commission of Health and Family Planning, 201540572

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Abstract: Objective · To evaluate the of long-chain non-coding RNA (lncRNA) lincRNA-BBOX1-2 in gastric cancer tissues and the value of diagnosis and prognosis of gastric cancer. Methods · The of lincRNA-BBOX1-2 was detectedreal-time quantitative PCR in 45 cases of gastric cancer and adjacent normal tissues. The correlations of lincRNA-BBOX1-2 with clinic-pathological features and clinical prognosis were analyzed. Results · The higher of lincRNA-BBOX1-2 was observed in the gastric cancer tissues (3.291±0.274 vs 1.125±0.075, P0.000) as compared with the adjacent normal tissues. Up-regulation of lincRNA-BBOX1-2 was associated with positive lymph node metastasis (P0.005, r0.172) and advanced clinical stage (P0.013, r0.137). Receiver operating characteristic curve analysis showed that the area under the curve (AUC) value was 0.916 (95%CI 0.859–0.972) for lincRNA-BBOX1-2 in predicting the occurrence of gastric cancer, and 0.720 (95%CI 0.565–0.875) for lincRNA-BBOX1-2 in predicting the lymph node metastasis. Conclusion · The up-regulation of lincRNA-BBOX1-2 in gastric cancer tissues is associated with the clinic-pathological features of gastric cancer. lincRNA-BBOX1-2 may be used as a potential diagnostic biomarker in patients with gastric cancer.

Key words: long-chain non-coding RNA (lncRNA), lincRNA-BBOX1-2, gastric cancer, TNM stage

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