›› 2019, Vol. 39 ›› Issue (4): 421-.doi: 10.3969/j.issn.1674-8115.2019.04.017

• Original article (Clinical research) • Previous Articles     Next Articles

Exposure status of multiple environmental pollutants during pregnancy: based on biomonitoring data Laizhou Wan Birth Cohort in Shandong

QIN Kai-li1*, LIU An-ming2*, YUAN Chong-gang3, SHI Rong1, YAO Qian1, CAI Chen4, ZHOU Yi-jun1, TIAN Ying1, 5, ZHANG Yan1, GAO Yu1   

  1. 1. Department of Environmental Health, Shanghai Jiao Tong University School of Public Health, Shanghai 200025, China; 2. Peoples Hospital of Weifang Binhai Economic and Technological Development Zone, Shandong Province, Weifang 262737, China; 3. Social Affairs Bureau of Weifang Binhai Economic and Technological Development Zone, Shandong Province, Weifang 262737, China; 4. Department of Pediatrics, Shanghai East Hospital, Tongji University, Shanghai 200120, China; 5. MOE and Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2019-04-28 Published:2019-05-23
  • Supported by:
    Young Scientists Fund in National Natural Science Foundation of China, 81602823; Natural Science Foundation of Science and Technology Commission of Shanghai Municipality, 17ZR1415800; Scientific Research Program of Shanghai Municipal Commission of Health and Family Planning, 201640174

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Abstract: Objective · To evaluate the levels of environmental pollutants including lead, mercury, organophosphorus pesticides (OPs), perfluoroalkyl and polyfluoroalkyl substances (PFASs) and triclosan (TCS) and further analyze the correlation between these pollutants in pregnant women. Methods · Pregnant women were recruited the Laizhou Wan Birth Cohort (LWBC) in Shandong September 2010 to December 2013. A total of 149 pregnant women were finally enrolled who completed questionnaires and provided sufficient biological samples for pollutants measurement including blood lead, blood mercury, urinary metabolites of OPs[dimethylphosphate (DMP), dimethylthiophosphate (DMTP), diethylphosphate (DEP), diethylthiophosphate (DETP), etc.], serum perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), as well as urinary TCS. Spearman correlation analysis and cosine cluster analysis were used to explore the correlation between pollutants. Results · The detection rates of lead, DMP, PFOA and PFOS were all 100.0%. And the detection rates of mercury, DMTP, DEP, DETP and TCS were 89.3%, 81.2%, 97.3%, 96.6% and 59.1%, respectively. The median and range of concentrations for lead, mercury, PFOA, PFOS and TCS were 28.40 (11.30–65.70) μg/L, 0.85 (

Key words: pregnant woman, heavy metal, organophosphorus pesticides (OPs), perfluoroalkyl and polyfluoroalkyl substances (PFASs), triclosan, correlation analysis

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