Research progress of non-coding RNA in myopia

doi:10.3969/j.issn.1674-8115.2022.03.016

Abstract

Abstract:

Non-coding RNA is a type of RNA that cannot be translated into protein, which was once considered “transcriptional noise”, including microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA). Research has found that non-coding RNA is involved in the physiological and pathological processes of several human diseases, such as cell proliferation, differentiation, apoptosis, and embryonic development. Recently, it has been considered that the expression profile changes of non-coding RNA in scleral tissue, retinal pigment epithelium cells (RPE), and aqueous humor of myopia patients and myopia animal models. The differential expression of non-coding RNA may contribute to the development of myopia by regulating the scleral extracellular matrix remodeling process, and choroidal blood flow and thickness. Therefore, this article aims to review the research progress in non-coding RNA of myopia to provide new directions and ideas for the diagnosis and treatment of myopia in the future.

Key words: non-coding RNA, microRNA, long non-coding RNA, circRNA, myopia

CLC Number:

R778.1⁺1

TEN Weijung, YUAN Ying, KE Bilian. Research progress of non-coding RNA in myopia[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(3): 369-374.

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References 53

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