Advances of regulation of endoplasmic reticulum stress and HIF-1 to VEGF in diabetic retinopathy

doi:10.3969/j.issn.1674-8115.2014.02.025

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Advances of regulation of endoplasmic reticulum stress and HIF-1 to VEGF in diabetic retinopathy

WANG Jing¹, ZHU Hong^2*, SHI Cai-hong¹

1.Department of Ophthalmology, the Third People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China; 2.Department of Ophthalmology, the First People′s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China

Online:2014-02-28 Published:2014-03-25
Supported by:
Natural Science Foundation of Shanghai，10ZR1418500

Abstract

Abstract:

Diabetic retinopathy is one of the most severe microvascular complications of diabetes mellitus, which can lead to irreversible blindness. The main pathological changes of DR are breakdown of blood-retinal barrier and neovascularization. Vascular endothelial growth factor (VEGF) is considered to be the most important intraocular neovascularization factor. Recent researches show that endoplasmic reticulum stress (ERS) and hypoxia-inducible factor-1 (HIF-1) can regulate the expression of VEGF and advance the progress of diabetic retinopathy together. This paper reviews the latest advance of the regulation mechanism of ERS and HIF-1 to VEGF.

Key words: diabetic retinopathy, endoplasmic reticulum stress, hypoxia-inducible factor-1, vascular endothelial growth factor

WANG Jing, ZHU Hong, SHI Cai-hong. Advances of regulation of endoplasmic reticulum stress and HIF-1 to VEGF in diabetic retinopathy[J]. , doi: 10.3969/j.issn.1674-8115.2014.02.025.

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Advances of regulation of endoplasmic reticulum stress and HIF-1 to VEGF in diabetic retinopathy

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