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Study on relevant factors of maximum standard uptake value of 18F-FDG PET/CT for lung cancer

WANG Shao-yan1, WANG Hui1, ZUO Chang-jing2, SUN Gao-feng2,CHEN Su-yun1, KONG Ling-shan2   

  1. 1.Department of Nuclear Medicine， Xinhua Hospital, Shanghai Jiao Tong Universality School of Medicine， Shanghai 200092， China; 2.Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433， China
  • Online:2015-07-28 Published:2015-08-27
  • Supported by:

    Foundation of Science and Technology Commission of Shanghai Municipality， 08411967800

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Abstract:

Objective  To investigate the relationship between maximum standard uptake value（SUVmax)  and clinicopathological features of lung cancer with PET/CT scan. Methods  A total of 82 patients with lung cancer who were confirmed by pathology underwent 18F-FDG PET/CT before therapy. The SUVmax of the focus was measured and recorded by region of interest (ROI) technique. SPSS 11.5 was used to statistically analyze the relationship between SUVmax and clinical factors, including gender, age, diameter of tumor (maximum value), pathological type, clinical staging, differentiation, etc. Results  Among 82 cases of lung cancer, 52 were adenocarcinoma, 23 were squamous cell carcinoma, and 7 were small cell cancer. The descending order of SUVmax of different pathological types was that of squamous cell carcinoma, small cell carcinoma, and adenocarcinoma. The difference of SUVmax of squamous cell carcinoma and adenocarcinoma was statistically significant (P<0.05). Tumors were divided into ≥3 cm group and <3 cm group. The differences of SUVmax of different pathological types of the <3 cm group were statistically significant (F=18.5, P<0.01). The differences of SUVmax of different pathological types of the ≥3 cm group were not statistically significant (F=0.45，P=0.72). The results of multiple linear regression analysis showed the SUVmax positively correlated with the maximum diameter of tumor and negatively correlated with the differentiation of tumor. The differentiation and diameter of tumor were multicollinear with SUVmax. After the diameter factor was adjusted, the regression model showed that the differentiation of tumor was the significant influencing factor (β=0.618, t=7.52, P<0.05), while staging and pathological type did not significantly affect the SUVmax. Conclusion  The SUVmax of lung cancer focus is relevant to the maximum diameter and differentiation of tumor, which are multicollinear with SUVmax. After the diameter factor has been adjusted, multivariate analysis shows that the differentiation of tumor is the significant influencing factor of SUVmax, while staging and pathological type do not significantly affect the SUVmax.

Key words: lung cancer, tomography, emission-computed, 18F-deoxyglucose, maximum standard uptake value