Abstract:

Although reprogramming of cancer glucose metabolism has attracted more and more attention, the underlying mechanism is not clear. Proteomic studies revealed that post-translational modifications (PTMs) of lysine residues exist in numerous cytoplasmic and mitochondrial proteins, suggesting they play a critical role in metabolic regulation. The present review summarizes the role of protein PTMs of lysine in the regulation of tumor glucose metabolism and further elucidates the association between PTMs and the regulation of tumor glucose metabolism, which may provide novel approaches to tumor treatment.

Key words: cancer, lysine, metabolism, post-translational modifications