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Role of protein post-translational modifications of lysine in tumor glucose metabolism

WANG Yun-qian, CHEN Ying-xuan   

  1. Shanghai Institute of Digestive Disease, Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200001, China
  • Online:2016-08-29 Published:2016-08-31
  • Supported by:

    National Natural Science Foundation of China, 81572303;Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152210


Although reprogramming of cancer glucose metabolism has attracted more and more attention, the underlying mechanism is not clear. Proteomic studies revealed that post-translational modifications (PTMs) of lysine residues exist in numerous cytoplasmic and mitochondrial proteins, suggesting they play a critical role in metabolic regulation. The present review summarizes the role of protein PTMs of lysine in the regulation of tumor glucose metabolism and further elucidates the association between PTMs and the regulation of tumor glucose metabolism, which may provide novel approaches to tumor treatment.

Key words: cancer, lysine, metabolism, post-translational modifications