›› 2018, Vol. 38 ›› Issue (2): 217-.doi: 10.3969/j.issn.1674-8115.2018.02.019

• Review • Previous Articles     Next Articles

Research progress of NLRP3 inflammasome in the pathogenesis of depression disorder

XING Meng-juan, PENG Dai-hui   

  1. Shanghai Key Laboratory of Severe Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2018-02-28 Published:2018-03-09
  • Supported by:
    General Program of National Natural Science Foundation of China, 81571327; Shanghai Health and Family Planning Commission Program, 201640003; Shanghai Mental Health  Center Program, 2017-YJ-15

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Abstract: Depression disorder is a kind of serious mental illness which poses high health risks and heavy financial burden to individuals and the society. Currently, there are many theories on the pathogenesis of depression disorder, such as neurotransmitter disorders, endocrine disorders, abnormal neuronal adaptability and plasticity, oxidative stress and mitochondrial dysfunction and so on. In the lately decade, the research of immune dysfunction in the pathogenesis of depression has become a newly hot-point. This review summarizes NLRP3 inflammasome in the pathogenesis of depression disorder.

Key words:  depression disorder, pathogenesis mechanism, NLRP3 inflammasome, cytokine