JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (5): 565-570.doi: 10.3969/j.issn.1674-8115.2021.05.002
• Basic research • Previous Articles Next Articles
Xiao-nan CHEN(), Jun-feng ZHANG, Chang-qian WANG, Hui-li ZHANG(
)
Online:
2021-05-28
Published:
2021-05-27
Contact:
Hui-li ZHANG
E-mail:cxn950118@sjtu.edu.cn;huilizhang815@163.com
Supported by:
CLC Number:
Xiao-nan CHEN, Jun-feng ZHANG, Chang-qian WANG, Hui-li ZHANG. Establishment of a novel mice model of heart failure with preserved ejection fraction[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(5): 565-570.
Body weight | Male | Female | ||||
---|---|---|---|---|---|---|
Control group (n=8) | HFpEF group (n=8) | P value | Control group (n=8) | HFpEF group (n=8) | P value | |
At the beginning of modeling/g | 23.53±1.17 | 23.38±1.28 | 0.869 | 20.43±1.37 | 20.43±0.53 | 0.999 |
4th week/g | 27.43±1.01 | 33.15±1.58 | 0.001 | 21.43±0.99 | 21.65±0.53 | 0.704 |
8th week/g | 27.33±1.68 | 40.70±7.07 | 0.001 | 20.98±0.41 | 23.30±1.45 | 0.022 |
12th week/g | 29.03±0.95 | 46.45±4.60 | 0.000 | 21.30±0.47 | 25.15±1.91 | 0.008 |
16th week/g | 31.63±1.04 | 47.00±3.11 | 0.000 | 20.45±0.26 | 26.78±2.55 | 0.003 |
Tab 1 Changes in body weight in the HFpEF mice
Body weight | Male | Female | ||||
---|---|---|---|---|---|---|
Control group (n=8) | HFpEF group (n=8) | P value | Control group (n=8) | HFpEF group (n=8) | P value | |
At the beginning of modeling/g | 23.53±1.17 | 23.38±1.28 | 0.869 | 20.43±1.37 | 20.43±0.53 | 0.999 |
4th week/g | 27.43±1.01 | 33.15±1.58 | 0.001 | 21.43±0.99 | 21.65±0.53 | 0.704 |
8th week/g | 27.33±1.68 | 40.70±7.07 | 0.001 | 20.98±0.41 | 23.30±1.45 | 0.022 |
12th week/g | 29.03±0.95 | 46.45±4.60 | 0.000 | 21.30±0.47 | 25.15±1.91 | 0.008 |
16th week/g | 31.63±1.04 | 47.00±3.11 | 0.000 | 20.45±0.26 | 26.78±2.55 | 0.003 |
Item | Male | Female | P value① | ||||
---|---|---|---|---|---|---|---|
Control group (n=8) | HFpEF group (n=8) | P value | Control group (n=8) | HFpEF group (n=8) | P value | ||
TAG/(mmol·L-1) | 1.19±0.25 | 1.50±0.73 | 0.039 | 0.90±0.24 | 1.56±0.56 | 0.022 | 0.384 |
TC/(mmol·L-1) | 2.65±0.22 | 3.98±0.61 | 0.003 | 2.40±0.46 | 3.89±0.22 | 0.000 | 0.012 |
HDL-Ch/(mmol·L-1) | 1.43±0.11 | 1.89±0.36 | 0.032 | 0.84±0.18 | 1.37±0.08 | 0.001 | 0.035 |
LDL-Ch/(mmol·L-1) | 0.15±0.01 | 0.33±0.03 | 0.000 | 0.16±0.05 | 0.27±0.04 | 0.008 | 0.084 |
Tab 2 Changes in blood lipid profiles in the HFpEF mice at the 16th week after modeling
Item | Male | Female | P value① | ||||
---|---|---|---|---|---|---|---|
Control group (n=8) | HFpEF group (n=8) | P value | Control group (n=8) | HFpEF group (n=8) | P value | ||
TAG/(mmol·L-1) | 1.19±0.25 | 1.50±0.73 | 0.039 | 0.90±0.24 | 1.56±0.56 | 0.022 | 0.384 |
TC/(mmol·L-1) | 2.65±0.22 | 3.98±0.61 | 0.003 | 2.40±0.46 | 3.89±0.22 | 0.000 | 0.012 |
HDL-Ch/(mmol·L-1) | 1.43±0.11 | 1.89±0.36 | 0.032 | 0.84±0.18 | 1.37±0.08 | 0.001 | 0.035 |
LDL-Ch/(mmol·L-1) | 0.15±0.01 | 0.33±0.03 | 0.000 | 0.16±0.05 | 0.27±0.04 | 0.008 | 0.084 |
Item | Male | Female | P value① | ||||
---|---|---|---|---|---|---|---|
Control group (n=8) | HFpEF group (n=8) | P value | Control group (n=8) | HFpEF group (n=8) | P value | ||
SBP/mmHg | 108.10±1.14 | 125.10±1.85 | 0.006 | 112.60±3.20 | 130.80±6.54 | 0.024 | 0.453 |
DBP/mmHg | 83.86±1.59 | 96.94±1.74 | 0.010 | 79.44±3.35 | 110.60±2.43 | 0.000 | 0.004 |
Tab 3 Changes in blood pressure in the HFpEF mice at the 16th week after modeling
Item | Male | Female | P value① | ||||
---|---|---|---|---|---|---|---|
Control group (n=8) | HFpEF group (n=8) | P value | Control group (n=8) | HFpEF group (n=8) | P value | ||
SBP/mmHg | 108.10±1.14 | 125.10±1.85 | 0.006 | 112.60±3.20 | 130.80±6.54 | 0.024 | 0.453 |
DBP/mmHg | 83.86±1.59 | 96.94±1.74 | 0.010 | 79.44±3.35 | 110.60±2.43 | 0.000 | 0.004 |
Item | Male | Female | ||||
---|---|---|---|---|---|---|
Control group (n=8) | HFpEF group (n=8) | P value | Control group (n=8) | HFpEF group (n=8) | P value | |
Heart weight/g | 0.138±0.014 | 0.166±0.023 | 0.029 | 0.114±0.010 | 0.133±0.012 | 0.020 |
Ratio of heart weight to body weight/% | 0.506±0.038 | 0.368±0.027 | 0.000 | 0.018±0.050 | 0.534±0.020 | 0.000 |
Tab 4 Changes in heart weight in the HFpEF mice at the 16th week after modeling
Item | Male | Female | ||||
---|---|---|---|---|---|---|
Control group (n=8) | HFpEF group (n=8) | P value | Control group (n=8) | HFpEF group (n=8) | P value | |
Heart weight/g | 0.138±0.014 | 0.166±0.023 | 0.029 | 0.114±0.010 | 0.133±0.012 | 0.020 |
Ratio of heart weight to body weight/% | 0.506±0.038 | 0.368±0.027 | 0.000 | 0.018±0.050 | 0.534±0.020 | 0.000 |
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