›› 2011, Vol. 31 ›› Issue (5): 663-.doi: 10.3969/j.issn.1674-8115.2011.05.029

• Review • Previous Articles     Next Articles

Research progress of Pax6 gene mutation and development of pancreas and diabetes mellitus

LU Yu-feng1,2, LIU Li-mei1   

  1. 1.Shanghai Diabetes Institute, Department of Endocrinology and Metabolism,the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China;2.Suzhou University, Suzhou 215006, China
  • Online:2011-05-28 Published:2011-05-27
  • Supported by:

    National Natural Science Foundation of China, 30771022;Shanghai Science and Technology Committee Foundation, 10XD1403400


Paired box 6(Pax6) is one of the members of Pax polygene transcription factor family, and plays an important role in the development of pancreas, α cell differentiation, transcription and activation of glucagon gene, β cell function and expression of insulin. Pax6 is the major gene in regulating the development of β cells, and its mutation contributes to the pathogenesis of impaired glucose tolerance and early-onset diabetes mellitus. The research progress of associations of Pax6 mutation with development of pancreas and diabetes mellitus is reviewed in this paper.

Key words: paired box 6 gene, mutation, pancreatic development, diabetes mellitus