›› 2013, Vol. 33 ›› Issue (2): 174-.doi: 10.3969/j.issn.1674-8115.2013.02.009

• Original article (Clinical research) • Previous Articles     Next Articles

Clinical value of 18F-fluorodeoxyglucose dual-head coincidence imaging in metastasis of differentiated thyroid cancer with positive Tg and negative 131I scan

YAO Xiao-qin, WANG Hui, MA Chao, FU Hong-liang   

  1. Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2013-02-28 Published:2013-03-07
  • Supported by:

    National Natural Science Foundation of China, 81271612

Abstract:

Objective To investigate the clinical value of 18F-fluorodeoxyglucose (18F-FDG) dual-head coincidence imaging in metastasis of differentiated thyroid cancer with positive thyroglobulin (Tg) and negative 131I scan. Methods Thirty-five patients with differentiated thyroid cancer and positive Tg and negative 131I whole-body scan after thyroidectomy were included. 18F-FDG dual-head coincidence imaging was performed in all the patients for the detection of metastatic lesions. The 18F-FDG imaging results were compared with pathological findings or results of continuous follow-up by Tg and other imaging modalities such as B ultrasound, CT and MRI. The sensitivity, specificity, accuracy and positive diagnosis value of 18F-FDG dual-head coincidence imaging in patients with differentiated thyroid cancer and positive Tg and negative 131I scan were obtained. Results Twenty-seven patients with metastatic differentiated thyroid cancer were confirmed by pathological examinations or continuous follow-up. The sensitivity, specificity, accuracy and positive diagnosis value of 18F-FDG dual-head coincidence imaging were 81.5%(22/27), 75.0%(6/8), 80.0%(28/35) and 91.7%(22/24) respectively. 18F-FDG dual-head coincidence imaging was well in line with pathological examinations and continuous follow-up in diagnosis of metastatic lesions in differentiated thyroid cancer with positive Tg and negative 131I scan (κ=0.499, P=0.006). Conclusion 18F-FDG dual-head coincidence imaging plays an important role in the diagnosis of differentiated thyroid cancer with positive Tg and negative 131I scan.

Key words: differentiated thyroid cancer, 18F-fluorodeoxyglucose dual-head coincidence, thyroglobulin, 131I