›› 2011, Vol. 31 ›› Issue (12): 1782-.doi: 10.3969/j.issn.1674-8115.2011.12.028

• 综述 • 上一篇    下一篇


钟一村, 李卫平, 狄 文   

  1. 上海交通大学 医学院附属仁济医院妇产科, 上海 200127
  • 出版日期:2011-12-28 发布日期:2012-01-04
  • 通讯作者: 李卫平, 电子信箱: lwp111@citiz.net。
  • 作者简介:钟一村(1972—), 男, 主治医师, 博士生;电子信箱: zhongyc1@sohu.com。

Mechanism of epithelial-mesenchymal transition in epithelial ovarian cancer

ZHONG Yi-cun, LI Wei-ping, DI Wen   

  1. Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2011-12-28 Published:2012-01-04



关键词: 卵巢上皮性癌, 上皮-间质转化, 转化生长因子, 表皮生长因子, 肝细胞生长因子, 内皮素-1, 骨成形蛋白4, 雌激素


Epithelial ovarian cancer (EOC) is the leading cause for death among gynecologic malignancies, which is closely related to its biological behaviors such as high potential of invasion and metastasis as well as chemoresistance and recurrence.The above features of EOC are closely associated with epithelial-mesenchymal transition (EMT). EMT means that epithelial cells lose the polarity, shape and arrangement, regains stromal cells' cytoskeleton and morphology, which significantly changes the cell migration phenotype. Thus, profound research and exploration of the mechanism of EMT in EOC may help to find new ways to treat EOC, and the blockage or interference with EMT in EOC may become a new target. The mechanism of EMT in EOC is reviewed in this paper.

Key words: epithelial ovarian cancer, epithelial-mesenchymal transition, transforming growth factor, epidermal growth factor, hepatocyte growth factor, endothelin1, bone morphogenetic protein 4, estrogen