上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (12): 1782-.doi: 10.3969/j.issn.1674-8115.2011.12.028

• 综述 • 上一篇    下一篇

卵巢上皮性癌发生上皮-间质转化的机制研究

钟一村, 李卫平, 狄 文   

  1. 上海交通大学 医学院附属仁济医院妇产科, 上海 200127
  • 出版日期:2011-12-28 发布日期:2012-01-04
  • 通讯作者: 李卫平, 电子信箱: lwp111@citiz.net。
  • 作者简介:钟一村（1972—）, 男, 主治医师, 博士生；电子信箱: zhongyc1@sohu.com。

Mechanism of epithelial-mesenchymal transition in epithelial ovarian cancer

ZHONG Yi-cun, LI Wei-ping, DI Wen   

  1. Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2011-12-28 Published:2012-01-04

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摘要：

卵巢上皮性癌(EOC)患者的病死率长期位居妇科恶性肿瘤之首，这与其极高的侵袭和转移力、耐药性以及复发率等一系列生物学行为密切相关。研究发现EOC的上述特性又与上皮-间质转化(EMT)密切相关。EMT即上皮细胞失去原有上皮细胞的极性、形态、排列方式，重新获得间质细胞的细胞骨架、形态，同时细胞的移动表型发生很大变化。深入研究和探讨诱导EOC发生EMT的机制，有助于寻找EOC治疗的新途径，阻断或干扰EMT的发生可能成为EOC治疗的新靶向。文章就EOC发生上皮-间质转化的机制研究进行综述。

关键词: 卵巢上皮性癌, 上皮-间质转化, 转化生长因子, 表皮生长因子, 肝细胞生长因子, 内皮素-1, 骨成形蛋白4, 雌激素

Abstract:

Epithelial ovarian cancer (EOC) is the leading cause for death among gynecologic malignancies, which is closely related to its biological behaviors such as high potential of invasion and metastasis as well as chemoresistance and recurrence.The above features of EOC are closely associated with epithelial-mesenchymal transition (EMT). EMT means that epithelial cells lose the polarity, shape and arrangement, regains stromal cells' cytoskeleton and morphology, which significantly changes the cell migration phenotype. Thus, profound research and exploration of the mechanism of EMT in EOC may help to find new ways to treat EOC, and the blockage or interference with EMT in EOC may become a new target. The mechanism of EMT in EOC is reviewed in this paper.

Key words: epithelial ovarian cancer, epithelial-mesenchymal transition, transforming growth factor, epidermal growth factor, hepatocyte growth factor, endothelin1, bone morphogenetic protein 4, estrogen