上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (12): 1786-.doi: 10.3969/j.issn.1674-8115.2011.12.029

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微小RNA与肾脏纤维化的研究进展

刘 剑, 王伟铭   

  1. 上海交通大学 医学院附属瑞金医院肾脏科, 上海 200025
  • 出版日期:2011-12-28 发布日期:2012-01-04
  • 作者简介:刘 剑（1987—）, 男, 硕士生；电子信箱: jim_liu@yeah.net。

Research progress of microRNA and renal fibrosis

LIU Jian, WANG Wei-ming   

  1. Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2011-12-28 Published:2012-01-04

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摘要：

微小RNA(miRNA)是一类长度约为22个核苷酸的非编码蛋白质RNA，通过与RNA结合，参与机体的生理和病理过程，并在细胞分化、增殖和凋亡等过程中发挥重要作用。研究发现，miRNA通过调控胶原沉积、纤维连接蛋白表达、间充质细胞转分化及转化生长因子β对肾脏的作用，参与肾脏纤维化的发生和进展。

关键词: 微小RNA, 纤维化, 肾脏

Abstract:

microRNA (miRNA), consisted of about 22 nucleotides, are noncoding small RNA. They can impact the target RNA, thus regulating the physiological and pathological processes and possessing an significant action in cell proliferation, apoptosis, and differentiation. It has been reported that miRNA, modulating the deposition of collagen, expression of fibronectin, epithelial-to-mesenchymal transition and effect of transforming growth factor-β in kidney, are involved in the mechanism of renal fibrosis.

Key words: microRNA, fibrosis, renal