上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (5): 670-.doi: 10.3969/j.issn.1674-8115.2012.05.031

• 综述 • 上一篇    下一篇

双酚A与胰岛素抵抗及2型糖尿病关系的研究进展

孙婉婉, 毕宇芳   

  1. 上海交通大学 医学院附属瑞金医院内分泌代谢病临床医学中心 |上海市内分泌研究所, 上海 200025
  • 出版日期:2012-05-28 发布日期:2012-06-01
  • 通讯作者: 毕宇芳, 电子信箱: byf10784@rjh.com.cn。
  • 作者简介:孙婉婉（1988—）, 女, 硕士生；电子信箱: sww19880325sww@sina.com。
  • 基金资助:

    上海市科委重大专项基金（09DZ1950200）

Research progress of correlation of bisphenol A with insulin resistance and type 2 diabetes

SUN Wan-wan, BI Yu-fang   

  1. Shanghai Institute for Endocrinology, Shanghai Clinical Center for Endocrine &|Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2012-05-28 Published:2012-06-01
  • Supported by:

    Key Special Program of Shanghai Science and Technology Committee, 09DZ1950200

PDF (PC)

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摘要：

双酚 A（BPA）是工业制造中广泛使用的一种化学物质，主要被用来制造塑料制品。日常生活中，人们通过饮食、呼吸、皮肤接触吸收BPA。BPA具有内分泌的干扰作用，被称为环境内分泌干扰物。BPA可以模拟雌激素的作用机制，影响胰岛B细胞以及雌激素敏感的组织如脂肪细胞、肝细胞、中枢神经系统，影响糖、脂代谢，引起胰岛素抵抗，影响脂肪细胞分化和脂质累积等，从而促进糖尿病的发生和发展。流行病学研究表明，BPA暴露水平过高可促进代谢性疾病，如胰岛素抵抗和2型糖尿病的发生。根据目前的研究结果，文章对BPA与胰岛素抵抗及2型糖尿病发生和发展的关系进行综述。

关键词: 双酚A, 2型糖尿病, 胰岛素抵抗, 环境内分泌干扰物

Abstract:

Bisphenol A (BPA) is a chemical widely used in industrial manufacture, which is mainly applied for plastic utility production. People gain exposure to BPA via diet, breathing and skin contact in daily life. BPA has endocrine disrupting function, and is named as endocrine disrupting chemical. BPA may simulate estrogen function, which may influence pancreas islet B cells and estrogen-sensitive tissues such as adipocytes, hepatocytes and central nervous system, affect metabolism of glucose and fat, cause insulin resistance, influence differentiation of adipocytes and fat accumulation, and promote the development and progress of diabetes. Epidemiological studies have revealed that excessive exposure to BPA may promote the  development of metabolic diseases such as insulin resistance and type 2 diabetes. The correlation of BPA with development and progress of insulin resistance and type 2 diabetes is reviewed in this paper.

Key words: bisphenol A, type 2 diabetes, insulin resistance, endocrine disrupting chemicals