上海交通大学学报(医学版) ›› 2018, Vol. 38 ›› Issue (6): 704-.doi: 10.3969/j.issn.1674-8115.2018.06.022

• 综述 • 上一篇    下一篇

载脂蛋白E基因型与常见重性精神疾病的关联性

余小燕 1, 2,李霞 1   

  1. 1. 上海交通大学医学院附属精神卫生中心,上海 200030;2.上海市长宁区精神卫生中心,上海 200335
  • 出版日期:2018-06-28 发布日期:2018-07-03
  • 通讯作者: 李霞,电子信箱:ja_1023@aliyun.com。
  • 作者简介:余小燕(1988—),女,住院医师,硕士生;电子信箱:m13817953593@163.com。
  • 基金资助:
    国家自然科学基金面上项目(81671402);上海市科学技术委员会医学引导项目(15411961400)

Relationship between the APOE genotypes and the common major psychosis

YU Xiao-yan1, 2, LI-Xia1   

  1. 1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Shanghai Changning District Mental Health Center, Shanghai 200335, China
  • Online:2018-06-28 Published:2018-07-03
  • Supported by:
    National Natural Science Foundation of China,81671402; Guiding Medical Project of Shanghai Science and Technology Committee, 15411961400

摘要: 载脂蛋白E(apolipoprotein E,APOE)是一种脂质转运蛋白,对维持神经的稳态及修复起重要作用。阿尔茨海默病(Alzheimers disease,AD)是神经退行性疾病。在较多的研究中发现,APOE基因型与AD存在密切关系。在临床上,AD主要表现为进行性认知功能减退,常伴有精神行为症状,而这些症状也在常见的重性精神疾病中存在。APOE基因型与这些疾病是否存在关联值得思考。该文就APOE基因型与常见重性精神疾病的关联性做一综述。

关键词: 载脂蛋白E, 基因型, 阿尔茨海默病, 重性精神疾病

Abstract:

Apolipoprotein E (APOE) is a lipid transfer protein, which plays an important role in maintaining the stabilization of nerve and recovering. Alzheimers disease (AD) is a neurodegenerative disorder. Most studies showed that APOE genotypes were closely related with AD. In clinical practice, AD is mainly manifested as progressive cognitive decline, and often accompaniedmental behavioral symptoms. These symptoms also exist in common severe mental illness. It is worth thinking about the correlation between APOE genotypes and these diseases. This article reviewed the relationship between the APOE genotypes and the common major psychosis.

Key words: apolipoprotein E, genotype, Alzheimers disease, major psychosis

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