基于昼夜节律基因的心肌梗死机制及治疗策略

doi:10.3969/j.issn.1674-8115.2025.12.013

摘要/Abstract

摘要：

哺乳动物的昼夜节律周期约为24 h，其内在节律主要由核心昼夜节律分子介导的转录-翻译反馈回路（transcription-translation feedback loops，TTFLs）调控，在维持生命活动和多种疾病的发生和发展中具有重要意义。昼夜节律基因通过调控代谢、氧化应激及炎症反应，参与心血管疾病的进程，尤其在心肌梗死的发生和发展中发挥关键作用。近年来，随着对昼夜节律基因的深入研究，其在心肌梗死中所涉及的分子机制逐渐明晰。该文综述核心昼夜节律分子（包括BMAL1、CLOCK、PER、CRY等）在心肌梗死发生和发展中的具体作用机制及其临床研究证据，探讨昼夜节律基因作为治疗靶点的潜力，并提出当前研究中存在的挑战及对未来的展望。研究进展表明，昼夜节律基因作为心肌梗死的治疗靶点具有广阔的应用前景，有望为制定临床治疗策略提供新的思路。

关键词: 昼夜节律基因, 心肌梗死, 分子时钟

Abstract:

The circadian rhythm of mammals spans approximately 24 h and is of great significance in maintaining life activities and contributing to the occurrence and progression of various diseases. This intrinsic rhythm is primarily regulated by transcription-translation feedback loops (TTFLs) mediated by core circadian molecules. Circadian genes participate in cardiovascular disease by regulating metabolism, oxidative stress, and inflammatory responses, and play a key role in myocardial infarction. In recent years, with advances in circadian gene research, the underlying molecular mechanisms in myocardial infarction have become increasingly elucidated. This review summarizes the specific molecular mechanisms and clinical research evidence related to core circadian molecules (such as BMAL1, CLOCK, PER, and CRY) in the context of myocardial infarction, explores the therapeutic potential of circadian genes, and discusses current research challenges and future directions in this field. These findings indicate that targeting circadian genes may have promising clinical applications, and could provide new strategies for the treatment of myocardial infarction.

Key words: circadian rhythm genes, myocardial infarction, molecular clock

中图分类号:

R543.3

黄铭望, 贾康妮, 闫小响. 基于昼夜节律基因的心肌梗死机制及治疗策略[J]. 上海交通大学学报（医学版）, 2025, 45(12): 1671-1678.

HUANG Mingwang, JIA Kangni, YAN Xiaoxiang. Mechanism and therapeutic strategies of myocardial infarction based on circadian rhythm genes[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(12): 1671-1678.

图/表 2

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