上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (5): 589-.

• 综述 • 上一篇    下一篇

Notch信号对血管新生调控作用的研究进展

姜 萌, 综述；何 奔, 审校   

  1. 上海交通大学 医学院仁济医院心内科, 上海 200001
  • 出版日期:2010-05-25 发布日期:2010-05-28
  • 作者简介:姜 萌（1976—）, 女, 主治医师, 博士；电子信箱: jiangmeng0919@163.com。
  • 基金资助:

    国家自然科学基金（30800453）和上海市青年科技启明星计划（10QA1404500）

Research advance in Notch signals in modulation of angiogenesis

JIANG Meng, reviewer；HE Ben, reviser   

  1. Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China
  • Online:2010-05-25 Published:2010-05-28
  • Supported by:

    National Natural Science Foundation of China, 30800453；Shanghai Rising-Star Program, 10QA1404500

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摘要：

对Notch信号在血管新生中作用的研究主要集中于内皮细胞的增生、尖细胞与茎细胞比例调节、动静脉分化及周细胞动员等方面。Notch调控血管生成的研究可为组织缺血、创伤和肿瘤等提供合理的治疗方向。该文就Notch信号转导通路的组成、Notch在生理性血管新生中的作用和机制，以及在脐血造血干细胞中的应用研究作一综述。

关键词: Notch, 血管新生, 脐血, 造血干细胞

Abstract:

The research in roles of Notch signals in angiogenesis mainly concentrates on endothelial cell proliferation, regulation of ratio of tip cells to stalk cells, arterial-venous differentiation and perithelial cell mobilization. The research on Notch signals in angiogenesis may enable us to launch rational treatment targeting tissue ischemia, trauma and tumors. The composition of Notch signaling, roles and mechanism of Notch in physiological angiogenesis and application research on cord blood hematopoietic stem cells are reviewed in this paper.

Key words: Notch, angiogenesis, cord blood, hematopoietic stem cell