上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (6): 609-.

• 专家论坛 •    下一篇

我国抑郁障碍的临床与发病机制研究现状

彭代辉, 方贻儒   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科, 上海 200030
  • 出版日期:2010-06-25 发布日期:2010-06-28
  • 作者简介:彭代辉（1972—）, 男, 副主任医师, 博士；电子信箱: pdhsh@126.com。

Clinical and pathogenesis researches on depressive disorder in China

PENG Dai-hui, FANG Yi-ru   

  1. Division of Mood Disorder, Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China
  • Online:2010-06-25 Published:2010-06-28

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摘要：

我国抑郁障碍的临床研究显示，有关抑郁障碍规范化防治路径的实施远未到位，针对其结局与转归的研究尚少且缺乏系统性。生物学机制研究涉及遗传学、神经生物化学与内分泌学、神经电生理与影像学等领域，然而具有特异性生物学标志的研究结果还不多，有些结果甚至相互矛盾。关于抑郁障碍临床与发病机制的研究工作任重而道远。该文对此进行综述，期望引起同道的重视并开展合作研究。

关键词: 抑郁障碍, 神经发生, 遗传方式, 电生理, 神经影像

Abstract:

The clinical researches of depressive disorder have indicated that the standardized guideline and practice for the prevention and treatment of depressive disorder are far from realization. Moreover, there is much room for improvement in the systematic studies of prognosis of depressive disorder. Researches of biological mechanism involve fields such as genetics, neurobiochemistry and endocrinology, neural electrophysiology and imaging. However, there have been less findings in specific biomarkers, and some results are even inconsistent. There is a long way to go for the studies of clinical and pathogenesis of depressive disorder. This paper hopes to arise more attention and collaboration on depressive disorder studies among the peers.

Key words: depressive disorder, neurogenesis, genetics, electrophysiology, neuroimaging