上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (11): 1509-.doi: 10.3969/j.issn.1674-8115.2011.11.001

• 专题报道（双相障碍） • 上一篇    下一篇

中文版心境障碍问卷在心境障碍患者中的应用

曹 岚, 苑成梅, 李则挚, 黄 佳, 王 勇, 洪 武, 彭代辉, 易正辉, 胡莺燕, 方贻儒   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科, 上海 200030
  • 出版日期:2011-11-28 发布日期:2011-11-29
  • 通讯作者: 方贻儒, 电子信箱: yirufang@yahoo.com.cn。
  • 作者简介:曹 岚（1979—）, 女, 主治医师, 硕士；电子信箱: cl020615@163.com。
  • 基金资助:

    国家自然科学基金（30971047）；国家高技术研究发展计划（“八六三”计划）(2006AA02Z430)；上海交通大学医学院“重点学科建设”基金（沪交医科[2008]-6）；“十五”国家科技攻关计划(2004BA720A21-02)；上海市卫生局公共卫生优秀青年人才项目(08GWQ075)；上海市卫生局青年科研项目(2007Y14)

Application of Chinese version of Mood Disorder Questionnaire in patients with mood disorder

CAO Lan, YUAN Cheng-mei, LI Ze-zhi, HUANG Jia, WANG Yong, HONG Wu, PENG Dai-hui, YI Zheng-hui, HU Ying-yan, FANG Yi-ru   

  1. Department of Mood Disorder, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2011-11-28 Published:2011-11-29
  • Supported by:

    National Natural Science Foundation of China, 30971047；National High Technology Research and Development Program of China, “863” Program, 2006AA02Z430；Shanghai Jiaotong University School of Medicine Foundation, 2008-6；National Key Technology Research and Development Program of China in “Tenth-Five Year Plan”, 2004BA720A21-02；Shanghai Municipal Health Bureau Foundation, O8GWQ075, 2007Y14

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摘要：

目的 探讨中文版心境障碍问卷（MDQ-C）筛查双相障碍的可行性，对抑郁障碍患者中有双相障碍可能的患者进行临床特征分析。方法 采用MDQ-C对308例心境障碍患者进行测评，包括双相障碍134例（双相障碍组）和抑郁障碍174例（抑郁障碍组）。对抑郁障碍组中MDQ得分≥5和MDQ得分＜5的患者的临床特征进行比较分析。结果 抑郁障碍组患者MDQ得分（3.90±2.92）明显低于双相障碍组（6.48±3.76），差异有统计学意义（t=6.574，P=0.000）；抑郁障碍组MDQ得分≥5的患者比例(34.5%，60/174)也明显低于双相障碍组(64.9%，87/134)，差异有统计学意义(χ2=28.121，P=0.000)。Logistic回归分析结果显示：MDQ得分≥5的抑郁障碍患者多为男性(优势比OR=0.342，P=0.004)和年龄<25岁(OR=0.952，P=0.001)患者，且首次发病存在食欲增强特征(OR=5.007，P=0.029)。结论 抑郁障碍患者中未被识别的双相障碍比例较高，MDQ-C可作为筛查工具提高双相障碍的识别率。男性、年龄<25岁、首次发病存在食欲增强不典型特征的抑郁发作患者有潜在双相障碍的可能。

关键词: 抑郁障碍, 双相障碍, 心境障碍问卷, 临床特征

Abstract:

Objective To evaluate the feasibility of Chinese version of Mood Disorder Questionnaire (MDQ-C) in screening patients with mood disorder, and analyse the clinical characteristics of patients with potential bipolar disorder in those with depression disorder. Methods Three hundred and eight patients with mood disorder were evaluated by MDQ-C, including 134 patients with bipolar disorder(bipolar disorder group) and 174 patients with depression disorder (depression disorder group). The clinical characteristics of patients with MDQ-C score≥5 and those with MDQ-C score＜5 in depression disorder group were compared and analysed. Results MDQ score in depression disorder group (3.90±2.92) was significantly lower than that in bipolar disorder group (6.48±3.76)(t=6.574, P=0.000). The percent of patients with MDQ-C score≥5 in depression disorder group(34.5%, 60/174) was significantly lower than that in bipolar disorder group (64.9%, 87/134)(χ2=28.121, P=0.000). Logistic regression analysis revealed that the majority of patients with depression disorder and MDQ-C score≥5 were males (odds ratio=0.342, P=0.004) and younger ones age<25 years (odds ratio=0.952, P=0.001), and were characterized by appetite increase at first episode (odds ratio=5.007, P=0.029). Conclusion A substantial proportion of patients with depression disorder may have unrecognized bipolar disorder, and MDQ-C may serve as a screening tool to increase the recognition of bipolar disorder. Patients with depression disorder and characteristics of male gender, age<25 years and appetite increase at first episode may potentially be those with bipolar disorder.

Key words: depression disorder, bipolar disorder, Mood Disorder Questionnaire, clinical characteristics