上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (10): 1378-.doi: 10.3969/j.issn.1674-8115.2012.10.022

• 综述 • 上一篇    下一篇

成纤维细胞生长因子19与糖脂蛋白质代谢的研究进展

倪 洁, 包玉倩   

  1. 上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病临床医学中心 上海市糖尿病研究所 上海市糖尿病重点实验室, 上海 200233
  • 出版日期:2012-10-28 发布日期:2012-11-05
  • 通讯作者: 包玉倩, 电子信箱: byq522@163.com。
  • 作者简介:倪 洁(1987—), 女, 硕士生；电子信箱: 309891384@qq.com。
  • 基金资助:

    国家重点基础研究发展计划(“九七三”项目)（2012CB524906）和国家自然科学基金（81170788）

Research progress of fibroblast growth factor 19 with glucose, lipid and protein metabolism

NI Jie, BAO Yu-qian   

  1. Department of Endocrinology and Metabolism, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China
  • Online:2012-10-28 Published:2012-11-05
  • Supported by:

    National Basic Research Program of China, “973” Program, 2012CB524906；National Natural Science Foundation of China, 81170788

PDF (PC)

1615

摘要：

成纤维细胞生长因子19（FGF19）是成纤维细胞生长因子家族成员之一，主要功能是调节胆汁酸平衡。近年来研究发现FGF19在糖脂蛋白质代谢中起重要作用，可促进肝脏糖原与蛋白质合成，抑制糖异生及三酰甘油和胆固醇的合成。随着对FGF19研究的不断深入，有望为糖尿病等代谢性疾病的治疗提供新的途径。

关键词: 成纤维细胞生长因子19, 胆汁酸, 糖脂代谢, 蛋白质合成

Abstract:

Fibroblast growth factor 19 (FGF19) is one of the members of the fibroblast growth factor family, and has been shown to regulate the bile acid balance. Recent studies have revealed that FGF19 plays an important role in glucose, lipid and protein metabolism, which could induce glycogen and protein synthesis, suppress gluconeogenesis and triglyceride and cholesterol synthesis in liver. These new findings of FGF19 may pave a new way for the treatment of metabolic diseases such as diabetes mellitus.

Key words: fibroblast growth factor 19, bile acid, glucose and lipid metabolism, protein synthesis