上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (1): 99-.doi: 10.3969/j.issn.1674-8115.2013.01.020

• 综述 • 上一篇    下一篇

Wnt信号通路调控间充质干细胞成骨分化的研究进展

陈小静, 高艳虹   

  1. 上海交通大学 医学院附属新华医院老年医学科, 上海 200092
  • 出版日期:2013-01-28 发布日期:2013-02-06
  • 通讯作者: 高艳虹, 电子信箱: yhgao2010@yahoo.com。
  • 作者简介:陈小静（1987—）, 女, 硕士生；电子信箱: cxj061@163.com。
  • 基金资助:

    国家自然科学基金（81101360）和上海市科委科研创新项目(12YZ053)

Research progress of Wnt signaling pathway in regulating osteogenic differentiation of mesenchymal stem cells

CHEN Xiao-jing, GAO Yan-hong   

  1. Department of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2013-01-28 Published:2013-02-06
  • Supported by:

    National Natural Science Foundation of China, 81101360； Shanghai Science and Technology Committee Foundation, 12YZ053

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摘要：

Wnt通路作为调控细胞生长、发育和分化的重要信号途径一直是医学研究的热点。近年来的研究表明，Wnt信号通路在调控间充质干细胞（MSCs）成骨分化过程中发挥重要作用，其机制已成为骨组织工程研究的热点，也为骨质疏松症等疾病的治疗提供了新思路。该文对Wnt信号通路调控MSCs成骨分化的研究进展进行综述。

关键词: 间充质干细胞, Wnt信号通路, 成骨分化, 骨形成

Abstract:

Wnt signaling pathway has been the focus of medical research as it plays a significant role in regulating the growth, development and differentiation of cells. Recent studies have revealed that Wnt signaling pathway may play an important role in regulating the osteogenic differentiation of mesenchymal stem cells (MSCs), the mechanism of which has been the hotspot of bone tissue engineering and provides a new way for the treatment of diseases such as osteoporosis. The research progress of Wnt signaling pathway in regulating osteogenic differentiation of MSCs is reviewed in this paper.

Key words: mesenchymal stem cells, Wnt signaling pathway, osteogenic differentiation, bone formation