上海交通大学学报（医学版）

上海交通大学学报（医学版）

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双相障碍的诊治与研究——机遇与挑战

方贻儒，吴志国，陈 俊   

  1. 上海交通大学  医学院附属精神卫生中心心境障碍科， 上海 200030
  • 出版日期:2014-04-28 发布日期:2014-05-13
  • 作者简介:方贻儒（1964—）， 男， 教授; 电子信箱: yirufang@aliyun.com。
  • 基金资助:

    国家自然科学基金（91232719）；“十二五”国家科技支撑项目（2012BAI01B04）；国家临床重点专科-上海市精神卫生中心（卫生部医政司2011-873）

Researches on the diagnosis and treatment of bipolar disorder: challenges and opportunities

FANG Yi-ru, WU Zhi-guo, CHEN Jun   

  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2014-04-28 Published:2014-05-13
  • Supported by:

    National Natural Science Foundation of China, 91232719; the “12th Five-year Plan” of National Key Technologies R&D Program, 2012BAI01B04; National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH, 2011-873

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摘要：

双相障碍临床表现复杂、病程多变，常导致临床识别不足、诊断不确定以及治疗困难。由此，学界开展了一系列研究，探索该病的特征与本质，并在循证医学的基础上践行有关诊断标准的修正以及治疗理念的纠正。该文从概念与诊断、神经生物学研究进展以及心境稳定剂治疗等方面对双相障碍的探索现状和前景进行评述。

关键词: 双相障碍, 诊断, 精神疾病诊断与统计手册, 神经生物学, 心境稳定剂

Abstract:

Bipolar disorder is a common mental illness with complicated clinical features and variant depressive/manic episode, resulting in under-recognition, misdiagnosis, and inappropriate treatment. Therefore, a series of researches have been carried out to explore its essential features and characteristics. Further more, diagnostic criteria and treatment principals have been modified based on the findings from evidence-based medicine. This paper reviews the current researches on bipolar disorder and their prospects from perspectives such as concepts and diagnoses, neurobiology research progresses, as well as the mood stabilizers treatment.

Key words: bipolar disorder, diagnosis, the diagnostic and statistical manual of mental disorders, neurobiology, mood stabilizer