上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

前列腺癌IVIM弥散加权成像与Gleason评分的相关性研究

陈小溪1，吴连明1，张晓斐1，陈伟波2，所世腾1，许建荣1   

  1. 1.上海交通大学 医学院附属仁济医院放射科， 上海 200127； 2.飞利浦（中国）投资有限公司医疗保健， 上海 200233
  • 出版日期:2014-06-28 发布日期:2014-06-30
  • 通讯作者: 许建荣, 电子信箱: xujianr@online.sh.cn。
  • 作者简介:陈小溪（1988—）， 女， 博士生; 电子信箱: chenxiaoxisjtu@hotmail.com。

Correlation between IVIM diffusion-weighted MR imaging and Gleason score of prostate cancer

CHEN Xiao-xi1, WU Lian-ming1, ZHANG Xiao-fei1, CHEN Wei-bo2, SUO Shi-teng1, XU Jian-rong1   

  1. 1.Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2.Philips Healthcare, Philips (China)
    Investment Co.Ltd, Shanghai 200233, China
  • Online:2014-06-28 Published:2014-06-30

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摘要：

目的 探讨体素内不相干运动（IVIM）弥散加权成像在前列腺癌诊断中的价值及其与Gleason评分的相关性。方法 回顾性分析38例前列腺癌患者与32例前列腺良性增生患者的多b值弥散加权图像资料，使用IVIM双指数模型计算肿瘤区与增生区的D值与f值，并分析D值与f值在肿瘤组与增生组间的差异，比较不同Gleason评分的前列腺癌的D值与f值的差异并分析其与Gleason评分的相关性。结果 肿瘤区的D值与f值显著低于增生区（P<0.05）。不同Gleason评分的前列腺癌的D值与f值差异有统计学意义（P<0.05）。前列腺癌的D值与Gleason评分呈负相关（r=-0.772，P<0.01），前列腺癌的f值与Gleason评分呈负相关（r=-0.780，P<0.01）。结论 D值与f值可用于前列腺癌诊断与评估，IVIM模型将有望从弥散与灌注两方面预测前列腺癌的恶性程度及预后。

关键词: 前列腺癌, 磁共振成像, 弥散加权成像, 体素内不相干运动

Abstract:

Objective To explore the value of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) for diagnosing prostate cancer and the correlation between IVIM DWI and the Gleason score. Methods The data of multi-b-value DWI of 38 patients with prostate cancer and 32 patients with benign prostate hyperplasia (BPH) were retrospectively analyzed. The D and f values of regions of prostate cancer and BPH were calculated by the IVIM bi-exponential model. The differences of D and f values of regions of prostate cancer and BPH were analyzed. The differences of D and f values of prostate cancer with different Gleason scores were compared and the correlation with the Gleason score was analyzed. Results D and f values of regions of prostate cancer were significantly lower than those of regions of BPH (P<0.05). The D and f values of prostate cancer with different Gleason scores were significantly different (P<0.05). The D value of prostate cancer was negatively correlated to the Gleason score (r=-0.772, P<0.01) and the f value of prostate cancer was negatively correlated to the Gleason score (r=-0.780，P<0.01). Conclusion D and f values can be used for the diagnosis and evaluation of prostate cancer. The IVIM model is expected to predict the aggressiveness and prognosis of prostate cancer from both diffusion and perfusion.

Key words: prostate cancer, magnetic resonance imaging, diffusion-weighted imaging, intravoxel incoherent motion