上海交通大学学报（医学版）

上海交通大学学报（医学版）

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蛋白质组学在白假丝酵母研究中的应用

刘锦燕 1，史册 2，王影 2，李文静 2，赵悦 2，朱巍巍 1，项明洁1，2   

  1. 1. 上海交通大学 医学院附属瑞金医院卢湾分院放免检验科，上海 200020；2.上海交通大学 医学院附属瑞金医院检验科，上海 200025
  • 出版日期:2016-12-28 发布日期:2016-12-29
  • 通讯作者: 项明洁，电子信箱：mjxiang123456@126.com。
  • 作者简介:刘锦燕（1981—），女，主管技师，硕士；电子信箱：stellaljy@163.com。
  • 基金资助:

    上海市医学重点专科配套课题（ZK2012A21）；2013年黄浦区卫生系统优秀青年人才培养计划配套课题（RCPY1407）

Application of proteomics to the study on Candida albicans

LIU Jin-yan1, SHI Ce2, WANG Ying2, LI Wen-jing2, ZHAO Yue2, ZHU Wei-wei1, XIANG Ming-jie1, 2   

  1. 1.Department of Laboratory Medicine, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China; 2.Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

  • Online:2016-12-28 Published:2016-12-29
  • Supported by:

    Program of Shanghai Key Specialty, ZK2012A21; Program of Excellent Youth Talents of Shanghai Municipal Huangpu District Health Bureau of China, RCPY1407

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摘要：

白假丝酵母(C.albicans)是人类最常见的条件性致病真菌，其引起的侵袭性C.albicans病是导致日益增多的免疫功能低下患者发病和死亡的原因之一。目前，临床抗真菌药物种类有限，耐药现象增多，新药物研发进展缓慢，导致临床治疗压力极大。近期发展起来的蛋白质组学研究提供了有效的新技术平台，已应用于C.albicans的致病因子、耐药机制、免疫应答和抗真菌药物作用机制研究等方面。该文对近年来蛋白质组学技术新发展及应用于C.albicans相关研究进展作一综述。

关键词: 蛋白质组学, 生物质谱, 白假丝酵母

Abstract:

Candida albicans (C.albicans) is the most common opportunistic human fungal pathogen causing invasive candidiasis, which is one of factors resulting in increasing morbidity and mortality in immunocompromised patients. Currently, limited types of antifungal drugs for clinical application, increased drug resistance, and slow progress of new drug development lead to more and more challenges in clinical treatment. Recently developed proteomics can provide a novel effective technology platform and has been applied to the study of C.albicans, including pathogenic factors, resistance mechanism, immune response, action mechanism of antifungal drugs, etc. In this paper, new development of proteomic technology and its application to the study on C.albicans were reviewed.

Key words: proteomics, mass spectrometry, Candida albicans