上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (8): 1064-.doi: 10.3969/j.issn.1674-8115.2017.08.003

• 论著（基础研究） • 上一篇    下一篇

二甲双胍对奥氮平灌胃大鼠胰岛素抵抗的改善作用

石佳丽1，张蕾1，乔颖1#，沈一峰1，李华芳1,2#   

  1. 1. 上海交通大学 医学院附属精神卫生中心，上海 200030；2. 上海市重性精神病重点实验室，上海 200030
  • 出版日期:2017-08-28 发布日期:2017-09-28
  • 通讯作者: 李华芳，电子信箱：lhlh_5@163.com。乔 颖，电子信箱：qiaoying_1978@aliyun.com。# 为共同通信作者
  • 作者简介:石佳丽（1991—），女，硕士生；电子信箱：17746530746@163.com
  • 基金资助:
    上海市科学技术委员会科研计划项目（13ZR1435800）；上海交通大学医学院转化医学协同创新中心课题（TM201506）

Ameliorative effect of metformin on insulin resistance induced by olanzapine gavage in rats

SHI Jia-li1, ZHANG Lei1, QIAO Ying1#, SHEN Yi-feng1, LI Hua-fang1,2#   

  1. 1. Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Shanghai Key Laboratory of Severe Mental Illness, Shanghai 200030, China
  • Online:2017-08-28 Published:2017-09-28
  • Supported by:
    Shanghai Committee of Science and Technology Research Project, 13ZR1435800; Translational Medicine Collaborative Innovation Center of Shanghai Jiao  Tong University School of Medicine Project, TM201506

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摘要： 目的 · 探讨二甲双胍对奥氮平灌胃大鼠胰岛素抵抗相关代谢参数的改善作用。方法 · 将 30 只雌性 SD 大鼠随机分为二甲双胍 干预组、奥氮平组和生理盐水对照组。第1 ～ 6 周，前 2 组给 5 mg/(kg · d) 奥氮平、第 3 组给等量生理盐水进行灌胃。第7 周开始， 干预组合用二甲双胍 500 mg/(kg · d)，奥氮平组合用等量生理盐水，继续灌胃 4 周。6 周末及 10 周末评估腹腔葡萄糖耐量和胰岛素抵 抗指数。结果 · 6 周末，干预组及奥氮平组腹腔葡萄糖耐量曲线下面积（P=0.040）、胰岛素抵抗指数（P=0.000）显著高于对照组。10 周末时，干预组糖耐量（P=0.015）及胰岛素抵抗指数明显低于奥氮平组（P=0.001）。 结论 · 二甲双胍治疗可以纠正奥氮平引起的糖耐 量受损，部分改善胰岛素抵抗。

关键词:  奥氮平, 二甲双胍, 胰岛素抵抗, 糖耐量

Abstract:

Objective · To investigate the effect of metformin on insulin resistance (IR)-related metabolic parameters in olanzapine-bearing rats.  Methods · Thirty female SD rats were randomly divided into metformin intervention group, olanzapine group and control group. During the first 6 weeks, 5 mg /(kg·d) olanzapine was given to the two test groups . The control group was given the same amount of saline. From the 7th week, the intervention group began to combine with metformin 500 mg / (kg·d), while the olanzapine group combined with the same amount of saline, continuing  for 4 weeks. At the end of 6th week and 10th week, intraperitoneal glucose tolerance and homeostasis model assessment IR index were assessed.  Results · The area under the glucose tolerance curve (P=0.040) and the IR index (P=0.000) were significantly higher for the intervention group and the olanzapine group than the control group at the end of 6th week. At the 10th weekend, the glucose tolerance (P=0.015) and IR index in the intervention group were significantly lower than those in the olanzapine group (P=0.001).  Conclusion · Metformin may rectify the impaired glucose tolerance and improve IR induced by olanzapine partly.

Key words: olanzapine, metformin, insulin resistance, glucose tolerance