上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (8): 984-.doi: 10.3969/j.issn.1674-8115.2018.08.021

• 综述 • 上一篇    下一篇

内源性外泌体作为纳米载药系统在心肌缺血治疗中的研究进展

洪婷，薛晓梅，何斌   

  1. 上海交通大学医学院附属新华医院麻醉与重症医学科，上海 200092
  • 出版日期:2018-08-28 发布日期:2018-09-11
  • 通讯作者: 何斌，电子信箱：hebin@xinhuamed.com.cn。
  • 作者简介:洪婷（1996—），女，硕士生；电子信箱： sunny@sjtu.edu.cn。
  • 基金资助:
    国家自然科学基金（ 81470390）；上海市教育委员会高峰高原学科建设计划（ 20152218）；上海申康医院发展中心促进市级医院临床技能与临床创新三年行动计划（ 16CR3006A）；上海市科学技术委员会科研计划项目（ 17411954700）

Research progress of endogenous exosomes as nano drug delivery system for treatment of myocardial ischemia

HONG Ting, XUE Xiao-mei, HE Bin   

  1. Department of Anesthesiology and SICU, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2018-08-28 Published:2018-09-11
  • Supported by:
    National Natural Science Foundation of China, 81470390; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20152218; Clinical Research Plan of Shanghai Hospital Development Center, 16CR3006A; Program of Science and Technology Commission of Shanghai Municipality, 17411954700

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摘要： 外泌体是一种由活细胞分泌的天然纳米微囊泡，是细胞间信息传递、物质交换的重要媒介。作为人体内源性载体，外泌体负载药物具有毒性低、无免疫原性、渗透性好、靶向性高等优点。在过去几年中，外泌体作为药物载体已成功负载小分子化学药物、核酸、蛋白质等。此外，这一新型载体也有望为临床治疗心肌缺血提供有力支持。该文就外泌体作为治疗心肌缺血载体的研究进展进行综述。

关键词: 心肌缺血, 治疗, 外泌体, 纳米载药系统

Abstract:

Exosomes are natural nano vesicles secretedliving cells, which play an important role in cellular communication and substance transportation. As a kind of carrier of human endogenous for drug transportation, many advantages of exosomes are in sight, for example, low toxicity, non immunogenicity, good permeability and high-targeting. In recent years, small molecular chemical drugs, nucleic acids and proteins have been successfully deliveredexosomes. This novel carrier is expected to provide strong support for the clinical treatment of myocardial ischemia. The research progress of exosomes as a kind ofcarrierinthetreatment of myocardial ischemiawasbriefly summarizedinthisarticle.

Key words: myocardial ischemia, treatment, exosome, nano-drug delivery system

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