上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (5): 505-.doi: 10.3969/j.issn.1674-8115.2019.05.011

• 论著·临床研究 • 上一篇    下一篇

孤独症谱系障碍患儿睡眠问题与行为表现的关系

李圆圆，文静，杨亭，郭敏，朱江，陈立，陈洁，李廷玉   

  1. 重庆医科大学附属儿童医院儿科研究所，儿童营养与健康重庆市重点实验室；儿童发育疾病研究教育部重点实验室；儿童发育重大疾病国家国际科技合作基地；儿科学重庆市重点实验室，重庆 400014
  • 出版日期:2019-05-28 发布日期:2019-07-26
  • 通讯作者: 李廷玉，电子信箱：tyli@vip.sina.com。
  • 作者简介:李圆圆（1992—），女，硕士生；电子信箱： 759392812@qq.com。
  • 基金资助:
    国家自然科学基金（81471518, 81771223）

Association between behavioral problems and sleep problems among children with autism spectrum disorder

LI Yuan-yuan, WEN Jing, YANG Ting, GUO Min, ZHU Jiang, CHEN Li, CHEN Jie, LI Ting-yu   

  1. Pediatric Research Institute, Chongqing Key Laboratroy of Child Nutrition and Health; Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing 400014, China
  • Online:2019-05-28 Published:2019-07-26
  • Supported by:
    National Natural Science Foundation of China, 81471518, 81771223

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摘要： 目的 ·探讨孤独症谱系障碍 (autism spectrum disorder，ASD)患儿睡眠问题与行为表现的关系。方法 ·纳入 356例 3～ 8岁 ASD患儿（ ASD组）及 225例健康儿童（对照组），采用睡眠习惯问卷（ Children's Sleep Habits Questionnaire，CSHQ）调查 2组儿童睡眠问题，采用社交反应量表（Social Responsiveness Scale，SRS）、孤独症儿童行为检查量表（Autism Behavior Checklist，ABC）、儿童孤独症评定量表（ Childhood Autism Rating Scale，CARS）对 ASD患儿行为症状进行评估。结果 ·根据 CSHQ总分，发现 ASD组儿童睡眠不良（总分≥ 41分）占 69.38%（247/356），远高于正常组儿童 47.56%（107/225）（P=0.000）；其中 ASD组儿童 CSHQ总分、入睡潜伏期、睡眠持续时间、夜醒、异态睡眠、睡眠呼吸障碍、白天嗜睡等方面得分均高于正常组儿童（均 P<0.05）。将 ASD患儿分为睡眠不良组与无睡眠不良组，发现睡眠不良的 ASD患儿 SRS总分、社交认知、社交沟通、社交动机、孤独症行为方式得分更高（均 P<0.05），ABC总分、感觉、交往、躯体运动、语言得分更高（均 P<0.05），且具有更高的 CARS量表得分（P=0.008），根据 CARS分层示发现睡眠不良组的 ASD患儿症状较重（ P=0.033）。结论 ·睡眠问题在 ASD患儿中具有较高的检出率，且有睡眠问题的 ASD患儿行为症状更重，提示睡眠问题可能与 ASD发病存在某种内在深层次联系，需要更加关注他们的睡眠问题，以期改善其康复效果。

关键词: 孤独症谱系障碍, 睡眠问题, 行为, 儿童

Abstract:

Objective · To explore the relationship between sleep problems and behavioral symptoms among the children with autism spectrum disorder (ASD). Methods · This study included 356 autistic children and 225 typically developing children aged 3-8 years. The Children’s Sleep Habits Questionnaire (CSHQ) was used to investigate the sleep problems of the two groups, and Social Responsiveness Scale (SRS), Childhood Autism Rating Scale (CARS), Autism Behavior Checklist (ABC) were used to assess the behavioral symptoms of the children with ASD. Results · According to the CSHQ total score, the prevalence of sleep problems was significantly higher in the children with ASD than that in the normally developing children [69.38% (245/356) vs. 47.56% (107/225), P=0.000]. The total scores of CSHQ, sleep onset delay, sleep duration, night waking, parasomnia, sleep disordered breathing, and daytime sleepiness in children with ASD were significantly higher than those in the control group (all P<0.05). Compared with the ASD children without sleep disorder, the ASD children with sleep disorder got higher SRS total scores, social cognition, social communication, social motivation and autistic mannerisms scores (all P<0.05). Moreover, the total scores of ABC, sensory stimuli sensorial, relating, body and object use, and language scores were higher in the ASD children with sleep disorder (all P<0.05). ASD children with sleep disorder had higher scores in CARS (P=0.008), and according to the CARS stratification, the children with ASD in the sleep disturbance group had more severe symptoms (P=0.033). Conclusion · Children with ASD have higher risk of sleep problems than the typically developing children. And sleep problems are significantly associated with behavior of children with ASD. Behavioral symptoms are severer in the ASD children with sleep problems. It is suggested that sleep problems may have some deep and internal relationship with the onset of ASD, and more attention should be paid to patients' sleep problems in order to improve their recovery effect.

Key words: autistic spectrum disorder, sleep problem, behavior, child

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