上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (11): 1515-1518.doi: 10.3969/j.issn.1674-8115.2020.11.014

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抗精神病药对精神分裂症患者静息态脑功能影响的研究进展

王颖婵，王继军   

  1. 上海交通大学医学院附属精神卫生中心脑电影像眼动研究室，上海200030
  • 出版日期:2020-11-28 发布日期:2021-01-13
  • 通讯作者: 王继军，电子信箱：jijunwang27@163.com。
  • 作者简介:王颖婵（1981—），女，博士生；电子信箱：wangyingchan1202@163.com。
  • 基金资助:
    国家重点研发计划（2016YFC1306803）；上海市自然科学基金（16ZR1430500）。

Research progress of effect of antipsychotics on resting brain function in patients with schizophrenia

WANG Ying-chan, WANG Ji-jun   

  1. Department of EEG & Neuroimaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2020-11-28 Published:2021-01-13
  • Supported by:
    National Key R&D Program of China (2016YFC1306803); Shanghai Municipal Natural Science Foundation (16ZR1430500).

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摘要： 抗精神病药是精神分裂症最重要的治疗手段。然而抗精神病药是如何影响脑功能从而发挥疗效，达到改善症状的目的目前仍不明确。静息态脑功能情况反映了大脑在静息状态下固有的活动模式，是所有认知活动的基础。了解抗精神病药物如何影响静息态脑功能有助于理解精神疾病的发病机制以及寻求治疗靶点。该文综述了抗精神病药治疗前后精神分裂症患者静息态脑区活动、脑网络功能连接以及全脑功能网络拓扑特性的研究现状，并对将来的研究方向作一展望。

关键词: 抗精神病药, 静息态, 脑网络, 动态功能连接

Abstract:

Antipsychotic drugs are the most commonly used treatment for schizophrenia. How antipsychotics affect brain function so as to improve clinical symptoms is still poorly understood. How brain works at rest reflects the inherent activity pattern of the brain in the resting state which is a foundation of all cognitive activities. To learn how antipsychotics affect brain function is helpful to understand the pathogenesis of mental illness and to seek better therapeutic targets. In this article, the changes of resting state brain area activities, brain network functional connectivities and the topology characteristics of whole brain functional network in the patients with schizophrenia before and after antipsychotic treatment are reviewed, and the future prospect is discussed.

Key words: antipsychotics drug, resting state, brain network, dynamic functional connectivity

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