上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (11): 1524-1529.doi: 10.3969/j.issn.1674-8115.2020.11.016

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程序性坏死的诱导剂和抑制剂及其在疾病中作用的研究进展

曹力元，牟 为   

  1. 上海交通大学公共卫生学院，上海 200025
  • 出版日期:2020-11-28 发布日期:2021-01-13
  • 通讯作者: 牟 为，电子信箱：weimu@shsmu.edu.cn。
  • 作者简介:曹力元（1996—），女，博士生；电子信箱：caoliyuan@sjtu.edu.cn。
  • 基金资助:
    国家自然科学基金(81803269)；上海市科技英才扬帆基金（18YF1412100）。

Inducers and inhibitors of necroptosis and their research progress in diseases

CAO Li-yuan, MU Wei   

  1. Shanghai Jiao Tong University School of Public Health, Shanghai 200025, China
  • Online:2020-11-28 Published:2021-01-13
  • Supported by:
    National Natural Science Foundation of China (81803269); Shanghai Sailing Program (18YF1412100).

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摘要： 程序性坏死作为细胞程序性死亡的重要方式之一，受到了越来越多的关注，它的发现颠覆了以往细胞坏死不受信号通路调控的观念。程序性坏死参与多种疾病的发生和发展过程，如炎症性疾病，心血管系统和神经系统疾病等。此外有研究表明，诱导程序性坏死可以抑制肿瘤细胞增殖或促进肿瘤细胞死亡，该发现有望用于治疗肿瘤和解决肿瘤耐药问题。由此可以看出，程序性坏死既能促进某些疾病的发生，又能成为治疗肿瘤的潜在方式。在不同的疾病中采取不同的治疗方式，抑制或诱导程序性坏死的发生，有望治疗多种临床疾病。因此，研究调控程序性坏死的诱导剂和抑制剂具有科学研究和临床应用的双重意义。该文回顾性阐述程序性坏死在不同病理条件下的分子机制，并归纳与其信号通路有关的诱导剂和抑制剂在多种疾病中的治疗潜能。

关键词: 程序性坏死, 诱导剂, 抑制剂, 肿瘤, 炎症

Abstract:

As an important form of programmed cell death, necroptosis is getting more and more attention and has overturned the previous assumption that cell necrosis was not controlled by signaling pathway. Necroptosis plays a role in initiation and development of many diseases, including inflammatory diseases, cardiovascular diseases and neurological diseases. Furthermore, research proved that inducing necroptosis of tumor cells could inhibit tumor cell growth or promote tumor cell death, which is a promising strategy to treat neoplasm and overcome drug resistance problem of tumor treatment. Therefore, necroptosis can promote the development of some diseases, and it could be a potential strategy to treat tumor. Inhibiting or inducing necroptosis in different diseases with different treatment strategies is expected to treat many clinical diseases. Therefore, developing necroptotic inducers and inhibitors is of great significance in fields of both scientific research and clinical application. This article reviews the underlying mechanism of necroptosis under different pathophysiological situations and innovatively summarizes therapeutic potentials of inducers and inhibitors related to necroptotic signaling pathways in various diseases.

Key words: necroptosis, inducer, inhibitor, tumor, inflammation

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