上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2020, Vol. 40 ›› Issue (2): 255-.doi: 10.3969/j.issn.1674-8115.2020.02.018

• 综述 • 上一篇    下一篇

细胞骨架相关蛋白4对肿瘤诊断和预后的作用

刘锦燕1，赵珺涛2，王恒如2，黄嘉仪2，王钰婷2，项明洁1, 2   

  1. 1. 上海交通大学医学院附属瑞金医院卢湾分院放免检验科，上海 200020；2.上海交通大学医学院附属瑞金医院检验科，上海 200025
  • 出版日期:2020-02-28 发布日期:2020-03-20
  • 通讯作者: 项明洁，电子信箱：mjxiang123456@126.com。
  • 作者简介:刘锦燕（1981—），女，副主任技师，硕士；电子信箱：stellaljy@163.com。
  • 基金资助:
    国家自然科学基金（81871706）；上海市“科技创新行动计划”产学研医合作领域项目（17DZ1930301-26）；上海市卫生和计划生育委员会课题（201840227，201740069）；上海市黄浦区卫生和计划生育委员会课题（HKM201702）。

Effect of cytoskeleton-associated protein 4 on tumor diagnosis and prognosis

LIU Jin-yan, ZHAO Jun-tao, WANG Heng-ru, HUANG Jia-yi, WANG Yu-ting, XIANG Ming-jie   

  1. 1. Radioimmunology and Clinical Laboratory, Luwan Branch, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China; 2. Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2020-02-28 Published:2020-03-20
  • Supported by:
    National Natural Science Foundation of China (81871706); "Science and Technology Innovation Action Plan" Projects in Industry-University-Research-Medical Cooperation Fields of Shanghai (17DZ1930301-26); Shanghai Municipal Planning Commission of Science and Research Fund (201840227, 201740069); Shanghai Huangpu District Municipal Planning Commission of Science and Research Fund (HKM201702).

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摘要： 细胞骨架相关蛋白4（cytoskeleton-associated protein 4, CKAP4）即p63，是一种非糖基化的Ⅱ型膜蛋白。CKAP4在组织、细胞以及血清中的表达可作为多种肿瘤的诊断性标志物，并与这些肿瘤的预后有一定相关性。该文对CKAP4的亚型和功能，以及CKAP4作为肿瘤诊断性、预后性指标的研究及应用进行了综述。

关键词: 细胞骨架相关蛋白4, p63, 肿瘤标志物, 诊断, 预后

Abstract:

Cytoskeleton-associated protein 4 (CKAP4), also known as p63, is a non-glycosylated type Ⅱ membrane protein. Expression of CKAP4 in tissues, cells and serum can be used as a diagnostic marker for a variety of tumors, and has a certain correlation with the prognosis of these tumors. This article reviews the subtype and function of CKAP4, as well as its research and application as a diagnostic and prognostic indicator of tumor.

Key words: cytoskeleton-associated protein 4 (CKAP4), p63, tumor marker, diagnosis, prognosis