FOXM1与肿瘤代谢关系的研究进展

doi:10.3969/j.issn.1674-8115.2024.10.015

上海交通大学学报（医学版） ›› 2024, Vol. 44 ›› Issue (10): 1323-1329.doi: 10.3969/j.issn.1674-8115.2024.10.015

FOXM1与肿瘤代谢关系的研究进展

李钰¹^,²(), 姜艺凡¹, 童荣亮¹, 陈迪宇¹, 吴健¹^,²()

^1.浙江大学医学院附属第一医院肝胆胰外科，杭州 310003
^2.卫生部多器官联合移植研究重点实验室，杭州 310003

收稿日期:2024-03-14 接受日期:2024-06-04 出版日期:2024-10-28 发布日期:2024-10-28
通讯作者: 吴健，电子信箱：drwujian@zju.edu.cn。
作者简介:李钰（1998—），男，硕士生；电子信箱：li_yu@zju.edu.cn。
基金资助:
浙江省自然科学基金华东医药企业创新发展联合基金资助项目(LHDMD22H310005)

Research progress in the relationship between FOXM1 and neoplasm metabolism

LI Yu¹^,²(), JIANG Yifan¹, TONG Rongliang¹, CHEN Diyu¹, WU Jian¹^,²()

^1.Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
^2.Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Hangzhou 310003, China.

Received:2024-03-14 Accepted:2024-06-04 Online:2024-10-28 Published:2024-10-28
Contact: WU Jian, E-mail: drwujian@zju.edu.cn.
Supported by:
Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(LHDMD22H310005)

摘要/Abstract

摘要：

FOXM1（forkhead box M1）是FOX转录因子家族中的重要成员，其已被证实通过转录调控作用影响诸多肿瘤细胞演进。此外，FOXM1高表达与多种癌症不良预后相关，其参与调控基因表达，细胞增殖、侵袭、转移和凋亡等多种生物学过程。肿瘤细胞中的代谢重编程是肿瘤的重要特征，决定了肿瘤细胞的存活、生长和增殖。随着研究的不断深入，越来越多的证据提示FOXM1在调节肿瘤细胞增殖与代谢之间起“桥梁”作用，成为衔接肿瘤细胞生物行为学与代谢的枢纽。该文对FOXM1与肿瘤细胞代谢关系的研究进展进行综述，旨在为研发基于FOXM1的新型靶向药物提供理论参考。

关键词: FOXM1, 肿瘤, 代谢, 抑制剂, 肿瘤微环境

Abstract:

FOXM1 (forkhead box M1) is an important member of the FOX transcription factor family and plays a critical role in driving the progression of multiple malignancies through its transcriptional regulatory functions. Moreover, the overexpression of FOXM1 is associated with poor prognosis in many types of cancer, as it regulates a variety of biological processes such as gene expression, cell proliferation, invasion, metastasis, and apoptosis. Presently, aberrant metabolic reprogramming has been considered as the major characteristic of cancer development, determining the survival, growth, and proliferation of tumor cells. Accumulating evidence suggests that FOXM1 serves as a "bridge" between metabolism and tumorigenesis. This review aims to provide a comprehensive summary of the research progress in the relationship between FOXM1 and tumor cell metabolism, offering theoretical insights for the development of novel anti-cancer drugs targeting FOXM1.

Key words: forkhead box M1 (FOXM1), tumor, metabolism, inhibitor, tumor microenvironment

中图分类号:

R730.22

李钰, 姜艺凡, 童荣亮, 陈迪宇, 吴健. FOXM1与肿瘤代谢关系的研究进展[J]. 上海交通大学学报（医学版）, 2024, 44(10): 1323-1329.

LI Yu, JIANG Yifan, TONG Rongliang, CHEN Diyu, WU Jian. Research progress in the relationship between FOXM1 and neoplasm metabolism[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024,(10): 1323-1329.

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FOXM1与肿瘤代谢关系的研究进展

Research progress in the relationship between FOXM1 and neoplasm metabolism

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